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The Alpha variant was not associated with excess nosocomial SARS-CoV-2 infection in a multi-centre UK hospital study.
Boshier, Florencia A T; Venturini, Cristina; Stirrup, Oliver; Guerra-Assunção, José Afonso; Alcolea-Medina, Adela; Becket, Angela H; Byott, Matthew; Charalampous, Themoula; Filipe, Ana da Silva; Frampton, Dan; Glaysher, Sharon; Khan, Tabassum; Kulasegara-Shylini, Raghavendran; Kele, Beatrix; Monahan, Irene M; Mollett, Guy; Parker, Matthew; Pelosi, Emanuela; Randell, Paul; Roy, Sunando; Taylor, Joshua F; Weller, Sophie J; Wilson-Davies, Eleri; Wade, Phillip; Williams, Rachel; Copas, Andrew J; Cutino-Moguel, Teresa; Freemantle, Nick; Hayward, Andrew C; Holmes, Alison; Hughes, Joseph; Mahungu, Tabitha W; Nebbia, Gaia; Nastouli, Eleni; Partridge, David G; Pope, Cassie F; Price, James R; Robson, Samuel C; Saeed, Kordo; Shin, Gee Yen; de Silva, Thushan I; Snell, Luke B; Thomson, Emma C; Witney, Adam A; Breuer, Judith.
  • Boshier FAT; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
  • Venturini C; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
  • Stirrup O; Institute for Global Health, University College London, London, United Kingdom.
  • Guerra-Assunção JA; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom; Department of Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
  • Alcolea-Medina A; Centre for Clinical Infection and Diagnostics Research, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom; Infection Sciences, Viapath, London, United Kingdom.
  • Becket AH; Centre for Enzyme Innovation, University of Portsmouth, Portsmouth PO1 2DT, United Kingdom; School of Biological Sciences, University of Portsmouth, Portsmouth PO1 2DY, United Kingdom.
  • Byott M; Advanced Pathogen Diagnostics Unit, University College London Hospitals NHS Foundation Trust, London, United Kingdom; The Francis Crick Institute, London, United Kingdom.
  • Charalampous T; Centre for Clinical Infection and Diagnostics Research, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
  • Filipe ADS; MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
  • Frampton D; Advanced Pathogen Diagnostics Unit, University College London Hospitals NHS Foundation Trust, London, United Kingdom; Division of Infection and Immunity, University College London, London, United Kingdom.
  • Glaysher S; Portsmouth Hospitals University NHS Trust, Queen Alexandra Hospital, Portsmouth PO6 3LY, United Kingdom.
  • Khan T; Division of Infection, The Royal London Hospital, Barts Health, United Kingdom.
  • Kulasegara-Shylini R; Division of Infection, The Royal London Hospital, Barts Health, United Kingdom.
  • Kele B; Division of Infection, The Royal London Hospital, Barts Health, United Kingdom.
  • Monahan IM; Institute for Infection and Immunity, St George's University of London, Cranmer Terrace, London SW17 0RE, United Kingdom.
  • Mollett G; MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
  • Parker M; Sheffield Bioinformatics Core, The University of Sheffield, Sheffield, United Kingdom; Sheffield Institute for Translational Neuroscience, The University of Sheffield, Sheffield, United Kingdom; Sheffield Biomedical Research Centre, The University of Sheffield, Sheffield, United Kingdom.
  • Pelosi E; Southampton Specialist Virology Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
  • Randell P; Department of Infection and Immunity, North West London Pathology, London, United Kingdom.
  • Roy S; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
  • Taylor JF; Department of Microbiology, South West London Pathology, Jenner Wing, St. George's Hospital, Blackshaw Road, London SW17 0QT, United Kingdom.
  • Weller SJ; Department of Virology, Royal Free London NHS Foundation Trust, London, United Kingdom.
  • Wilson-Davies E; Southampton Specialist Virology Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
  • Wade P; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom; The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, United Kingdom.
  • Williams R; Department of Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
  • Copas AJ; Institute for Global Health, University College London, London, United Kingdom.
  • Cutino-Moguel T; Division of Infection, The Royal London Hospital, Barts Health, United Kingdom.
  • Freemantle N; Institute for Clinical Trials and Methodology, University College London, London, United Kingdom.
  • Hayward AC; Institute of Epidemiology and Health Care, University College London, London, United Kingdom.
  • Holmes A; Department of Infectious Disease, Faculty of Medicine, Imperial College London, United Kingdom; Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom.
  • Hughes J; MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
  • Mahungu TW; Department of Virology, Royal Free London NHS Foundation Trust, London, United Kingdom.
  • Nebbia G; Centre for Clinical Infection and Diagnostics Research, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom; Department of Infectious Diseases, Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom.
  • Nastouli E; Great Ormond Street Institute of Child Health, University College London, London, United Kingdom; Advanced Pathogen Diagnostics Unit, University College London Hospitals NHS Foundation Trust, London, United Kingdom; Department of Clinical Virology, University College London Hospitals NHS Foundation
  • Partridge DG; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom; The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, United Kingdom.
  • Pope CF; Institute for Infection and Immunity, St George's University of London, Cranmer Terrace, London SW17 0RE, United Kingdom; Infection Care Group, St George's University Hospitals NHS Foundation Trust, Blackshaw Road, London SW17 0QT, United Kingdom.
  • Price JR; Imperial College Healthcare NHS Trust, London, United Kingdom.
  • Robson SC; Centre for Enzyme Innovation, University of Portsmouth, Portsmouth PO1 2DT, United Kingdom; School of Biological Sciences, University of Portsmouth, Portsmouth PO1 2DY, United Kingdom; School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, United Kingdom.
  • Saeed K; Department of Infection, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, United Kingdom; Faculty of Medicine, Clinical and Experimental Sciences, University of Southampton, Tremona Road, Southampton, United Kingdom.
  • Shin GY; Department of Clinical Virology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
  • de Silva TI; Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom; The Florey Institute for Host-Pathogen Interactions and Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Sheffield, United Kingdom.
  • Snell LB; Centre for Clinical Infection and Diagnostics Research, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom; Department of Infectious Diseases, Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom.
  • Thomson EC; MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
  • Witney AA; Institute for Infection and Immunity, St George's University of London, Cranmer Terrace, London SW17 0RE, United Kingdom.
  • Breuer J; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom; Department of Microbiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom. Electronic address: j.breuer@u
J Infect ; 83(6): 693-700, 2021 12.
Article in English | MEDLINE | ID: covidwho-1446866
ABSTRACT

OBJECTIVES:

Recently emerging SARS-CoV-2 variants have been associated with an increased rate of transmission within the community. We sought to determine whether this also resulted in increased transmission within hospitals.

METHODS:

We collected viral sequences and epidemiological data of patients with community and healthcare associated SARS-CoV-2 infections, sampled from 16th November 2020 to 10th January 2021, from nine hospitals participating in the COG-UK HOCI study. Outbreaks were identified using ward information, lineage and pairwise genetic differences between viral sequences.

RESULTS:

Mixed effects logistic regression analysis of 4184 sequences showed healthcare-acquired infections were no more likely to be identified as the Alpha variant than community acquired infections. Nosocomial outbreaks were investigated based on overlapping ward stay and SARS-CoV-2 genome sequence similarity. There was no significant difference in the number of patients involved in outbreaks caused by the Alpha variant compared to outbreaks caused by other lineages.

CONCLUSIONS:

We find no evidence to support it causing more nosocomial transmission than previous lineages. This suggests that the stringent infection prevention measures already in place in UK hospitals contained the spread of the Alpha variant as effectively as other less transmissible lineages, providing reassurance of their efficacy against emerging variants of concern.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cross Infection / COVID-19 Type of study: Controlled clinical trial / Randomized controlled trials / Risk factors Topics: Variants Limits: Humans Country/Region as subject: Europa Language: English Journal: J Infect Year: 2021 Document Type: Article Affiliation country: J.jinf.2021.09.022

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cross Infection / COVID-19 Type of study: Controlled clinical trial / Randomized controlled trials / Risk factors Topics: Variants Limits: Humans Country/Region as subject: Europa Language: English Journal: J Infect Year: 2021 Document Type: Article Affiliation country: J.jinf.2021.09.022