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Single-nucleotide polymorphism in chronic rhinosinusitis: A systematic review.
Antonino, Maniaci; Nicolò, Musso; Jerome Renee, Lechien; Federico, Merlino; Chiara, Viglianisi; Stefano, Stracquadanio; Maria, Santagati; Salvatore, Cocuzza; Antonio, Bonanno; Calvo-Henriquez, Christian; Stefania, Stefani; La Mantia, Ignazio.
  • Antonino M; Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", ENT Section, ENT Department of University of Catania, Catania, Italy.
  • Nicolò M; Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, Catania, Italy.
  • Jerome Renee L; Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, Catania, Italy.
  • Federico M; Research Committee of the Young Otolaryngologists, International Federations of ORL Societies, Paris, France.
  • Chiara V; Department of Human Anatomy and Experimental Oncology, School of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons, Mons, Belgium.
  • Stefano S; Department of Otorhinolaryngology-Head and Neck Surgery, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.
  • Maria S; Department of Otolaryngology-Head and Neck Surgery, Foch Hospital, University of Paris-Saclay), Paris, France.
  • Salvatore C; Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", ENT Section, ENT Department of University of Catania, Catania, Italy.
  • Antonio B; Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", ENT Section, ENT Department of University of Catania, Catania, Italy.
  • Calvo-Henriquez C; Department of Biomedical and Biotechnological Sciences (BIOMETEC), Medical Molecular Microbiology and Antibiotic Resistance Laboratory (MMARLab), University of Catania, Catania, Italy.
  • Stefania S; Department of Biomedical and Biotechnological Sciences (BIOMETEC), Medical Molecular Microbiology and Antibiotic Resistance Laboratory (MMARLab), University of Catania, Catania, Italy.
  • La Mantia I; Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", ENT Section, ENT Department of University of Catania, Catania, Italy.
Clin Otolaryngol ; 47(1): 14-23, 2022 01.
Article in English | MEDLINE | ID: covidwho-1447927
ABSTRACT

OBJECTIVES:

We performed a systematic review on single-nucleotide polymorphisms and risk-related chronic rhinosinusitis. DESIGN AND

SETTING:

A comprehensive review of the last 20 years' English language literature regarding chronic rhinosinusitis and single-nucleotide polymorphisms was performed. We included in the synthesis all the papers reporting gene variation implicated in the pathogenesis of chronic inflammation and polyps.

RESULTS:

We found 12 papers with 9127 patients, of which 2739 CRS cases and 6388 controls. The major comorbidities reported related to chronic rhinosinusitis were atopy in 4555 (49.9%), asthma in 4594 (50.33%), Samter Triad in 448 (4.9%) and eosinophilia in 391 subjects (4.28%).

CONCLUSION:

Our systematic review revealed the major SNPs significantly associated with chronic rhinosinusitis and the specific pathways involved. Given the presence of different extraction methods and samples sequencing, further studies with larger courts are necessary to identify significative single-nucleotide polymorphisms.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sinusitis / Rhinitis / Polymorphism, Single Nucleotide Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Clin Otolaryngol Journal subject: Otolaryngology Year: 2022 Document Type: Article Affiliation country: Coa.13870

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sinusitis / Rhinitis / Polymorphism, Single Nucleotide Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Clin Otolaryngol Journal subject: Otolaryngology Year: 2022 Document Type: Article Affiliation country: Coa.13870