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Adequate immune response after SARS-CoV-2 infection and single dose vaccination despite rapid heart transplantation.
Erbel-Khurtsidze, Sophiko; Immohr, Moritz Benjamin; Akhyari, Payam; Tudorache, Igor; Aubin, Hug; Bruno, Raphael Romano; Westenfeld, Ralf; Feldt, Torsten; Lübke, Nadine; Lichtenberg, Artur; Boeken, Udo.
  • Erbel-Khurtsidze S; Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, Duesseldorf, 40225, Germany.
  • Immohr MB; Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, Duesseldorf, 40225, Germany.
  • Akhyari P; Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, Duesseldorf, 40225, Germany.
  • Tudorache I; Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, Duesseldorf, 40225, Germany.
  • Aubin H; Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, Duesseldorf, 40225, Germany.
  • Bruno RR; Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Duesseldorf, Germany.
  • Westenfeld R; Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Duesseldorf, Germany.
  • Feldt T; Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Duesseldorf, Germany.
  • Lübke N; Institute of Virology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Duesseldorf, Germany.
  • Lichtenberg A; Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, Duesseldorf, 40225, Germany.
  • Boeken U; Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, Duesseldorf, 40225, Germany.
ESC Heart Fail ; 8(6): 5568-5571, 2021 12.
Article in English | MEDLINE | ID: covidwho-1449922
ABSTRACT
Adequate immune response to vaccination remains a challenge in patients after solid organ transplantation. We report a case of a 61-year-old male patient who received a left ventricular assist device as a bridge to transplant therapy. Three months before transplantation, he suffered mild SARS-CoV-2 infection and was successfully discharged thereafter. Eight days before his successful heart transplantation, he received mRNA BNT 162b2 vaccination. Immediately after transplantation, we detected sufficient rise of nucleocapsid and spike antibodies despite immune suppression therapy. We suspect potential booster effects of the previous SARS-CoV-2 infection giving rise to adequate immune response following single vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Heart Transplantation / COVID-19 Type of study: Case report Topics: Vaccines Limits: Humans / Male / Middle aged Language: English Journal: ESC Heart Fail Year: 2021 Document Type: Article Affiliation country: Ehf2.13635

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Heart Transplantation / COVID-19 Type of study: Case report Topics: Vaccines Limits: Humans / Male / Middle aged Language: English Journal: ESC Heart Fail Year: 2021 Document Type: Article Affiliation country: Ehf2.13635