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The serum amino acid profile in COVID-19.
Atila, Alptug; Alay, Handan; Yaman, Mehmet Emrah; Akman, Tugrul Cagri; Cadirci, Elif; Bayrak, Burak; Celik, Saffet; Atila, Nihal Efe; Yaganoglu, Aycan Mutlu; Kadioglu, Yucel; Halici, Zekai; Parlak, Emine; Bayraktutan, Zafer.
  • Atila A; Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey. alptug@atauni.edu.tr.
  • Alay H; Department of Infectious Diseases and Clinical Microbiology, Ataturk University Faculty of Medicine, 25240, Erzurum, Turkey.
  • Yaman ME; Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey.
  • Akman TC; Department of Analytical Chemistry, Faculty of Pharmacy, Erzincan Binali Yildirim University, 25240, Erzurum, Turkey.
  • Cadirci E; Department of Pharmacology, Ataturk University Faculty of Medicine, 25240, Erzurum, Turkey.
  • Bayrak B; Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey.
  • Celik S; Technology Research and Development Application and Research Center, Trakya University, 22030, Edirne, Turkey.
  • Atila NE; Department of Otorhinolaryngology, Erzurum Regional Training and Research Hospital, 25240, Erzurum, Turkey.
  • Yaganoglu AM; Department of Animal Science, College of Agriculture, Ataturk University, 25240, Erzurum, Turkey.
  • Kadioglu Y; Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240, Erzurum, Turkey.
  • Halici Z; Department of Pharmacology, Ataturk University Faculty of Medicine, 25240, Erzurum, Turkey.
  • Parlak E; Department of Infectious Diseases and Clinical Microbiology, Ataturk University Faculty of Medicine, 25240, Erzurum, Turkey.
  • Bayraktutan Z; Department of Biochemistry, Ataturk University Faculty of Medicine, 25240, Erzurum, Turkey.
Amino Acids ; 53(10): 1569-1588, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1449969
ABSTRACT
The pandemic of the coronavirus disease (COVID-19) caused by SARS-CoV-2 affects millions of people worldwide. There are still many unknown aspects to this infection which affects the whole world. In addition, the potential impacts caused by this infection are still unclear. Amino acid metabolism, in particular, contains significant clues in terms of the development and prevention of many diseases. Therefore, this study aimed to compare amino acid profile of COVID-19 and healthy subject. In this study, the amino acid profiles of patients with asymptomatic, mild, moderate, and severe/critical SARS-CoV-2 infection were scanned with LC-MS/MS. The amino acid profile encompassing 30 amino acids in 142 people including 30 control and 112 COVID-19 patients was examined. 20 amino acids showed significant differences when compared to the control group in COVID-19 patient groups with different levels of severity in the statistical analyses conducted. It was detected that the branched-chain amino acids (BCAAs) changed in correlation with one another, and L-2-aminobutyric acid and L-phenylalanine had biomarker potential for COVID-19. Moreover, it was concluded that L-2-aminobutyric acid could provide prognostic information about the course of the disease. We believe that a new viewpoint will develop regarding the diagnosis, treatment, and prognosis as a result of the evaluation of the serum amino acid profiles of COVID-19 patients. Determining L-phenylalanine and L-2-aminobutyric levels can be used in laboratories as a COVID-19-biomarker. Also, supplementing COVID patients with taurine and BCAAs can be beneficial for treatment protocols.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Amino Acids Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Amino Acids Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: S00726-021-03081-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Amino Acids Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Amino Acids Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: S00726-021-03081-w