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Urgent Guidance for Navigating and Circumventing the QTc-Prolonging and Torsadogenic Potential of Possible Pharmacotherapies for Coronavirus Disease 19 (COVID-19).
Giudicessi, John R; Noseworthy, Peter A; Friedman, Paul A; Ackerman, Michael J.
  • Giudicessi JR; Department of Cardiovascular Medicine, Clinician-Investigator Training Program, Mayo Clinic, Rochester, MN; Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Mayo Clinic, Rochester, MN.
  • Noseworthy PA; Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Mayo Clinic, Rochester, MN.
  • Friedman PA; Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Mayo Clinic, Rochester, MN.
  • Ackerman MJ; Department of Cardiovascular Medicine, Division of Heart Rhythm Services, Mayo Clinic, Rochester, MN; Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, MN; Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice
Mayo Clin Proc ; 95(6): 1213-1221, 2020 06.
Article in English | MEDLINE | ID: covidwho-1450185
Semantic information from SemMedBD (by NLM)
1. Pharmacotherapy TREATS COVID-19
Subject
Pharmacotherapy
Predicate
TREATS
Object
COVID-19
2. hydroxychloroquine PREDISPOSES Sudden Cardiac Death
Subject
hydroxychloroquine
Predicate
PREDISPOSES
Object
Sudden Cardiac Death
3. lopinavir / Ritonavir PREDISPOSES Sudden Cardiac Death
Subject
lopinavir / Ritonavir
Predicate
PREDISPOSES
Object
Sudden Cardiac Death
4. Eye LOCATION_OF COVID-19
Subject
Eye
Predicate
LOCATION_OF
Object
COVID-19
5. Heart Ventricle LOCATION_OF Drug induced arrhythmia
Subject
Heart Ventricle
Predicate
LOCATION_OF
Object
Drug induced arrhythmia
6. Post-Exposure Prophylaxis TREATS Drug induced arrhythmia
Subject
Post-Exposure Prophylaxis
Predicate
TREATS
Object
Drug induced arrhythmia
7. Possible PREDISPOSES exposure (to) disease
Subject
Possible
Predicate
PREDISPOSES
Object
exposure (to) disease
8. Pharmacotherapy TREATS COVID-19
Subject
Pharmacotherapy
Predicate
TREATS
Object
COVID-19
9. hydroxychloroquine PREDISPOSES Sudden Cardiac Death
Subject
hydroxychloroquine
Predicate
PREDISPOSES
Object
Sudden Cardiac Death
10. lopinavir / Ritonavir PREDISPOSES Sudden Cardiac Death
Subject
lopinavir / Ritonavir
Predicate
PREDISPOSES
Object
Sudden Cardiac Death
11. Eye LOCATION_OF COVID-19
Subject
Eye
Predicate
LOCATION_OF
Object
COVID-19
12. Heart Ventricle LOCATION_OF Drug induced arrhythmia
Subject
Heart Ventricle
Predicate
LOCATION_OF
Object
Drug induced arrhythmia
13. Post-Exposure Prophylaxis TREATS Drug induced arrhythmia
Subject
Post-Exposure Prophylaxis
Predicate
TREATS
Object
Drug induced arrhythmia
14. Possible PREDISPOSES exposure (to) disease
Subject
Possible
Predicate
PREDISPOSES
Object
exposure (to) disease
ABSTRACT
As the coronavirus disease 19 (COVID-19) global pandemic rages across the globe, the race to prevent and treat this deadly disease has led to the "off-label" repurposing of drugs such as hydroxychloroquine and lopinavir/ritonavir, which have the potential for unwanted QT-interval prolongation and a risk of drug-induced sudden cardiac death. With the possibility that a considerable proportion of the world's population soon could receive COVID-19 pharmacotherapies with torsadogenic potential for therapy or postexposure prophylaxis, this document serves to help health care professionals mitigate the risk of drug-induced ventricular arrhythmias while minimizing risk of COVID-19 exposure to personnel and conserving the limited supply of personal protective equipment.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Long QT Syndrome / Torsades de Pointes / Death, Sudden, Cardiac / Ritonavir / Risk Adjustment / Lopinavir / Hydroxychloroquine Type of study: Etiology study / Clinical Practice Guide Language: English Journal: Mayo Clin Proc Year: 2020 Document Type: Article Affiliation country: J.mayocp.2020.03.024

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Long QT Syndrome / Torsades de Pointes / Death, Sudden, Cardiac / Ritonavir / Risk Adjustment / Lopinavir / Hydroxychloroquine Type of study: Etiology study / Clinical Practice Guide Language: English Journal: Mayo Clin Proc Year: 2020 Document Type: Article Affiliation country: J.mayocp.2020.03.024