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Follicular Helper T Cells in the Immunopathogenesis of SARS-CoV-2 Infection.
Cui, Dawei; Tang, Yuan; Jiang, Qi; Jiang, Daixi; Zhang, Yun; Lv, Yan; Xu, Dandan; Wu, Jian; Xie, Jue; Wen, Chengping; Lu, Liwei.
  • Cui D; Department of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Tang Y; Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, Hong Kong, SAR China.
  • Jiang Q; Chongqing International Institute for Immunology, Chongqing, China.
  • Jiang D; Department of Blood Transfusion, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, China.
  • Zhang Y; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Chi
  • Lv Y; School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, China.
  • Xu D; Department of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Wu J; Department of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Xie J; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Chi
  • Wen C; Department of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Lu L; School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, China.
Front Immunol ; 12: 731100, 2021.
Article in English | MEDLINE | ID: covidwho-1450811
ABSTRACT
Coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a serious infectious disease that has led to a global pandemic with high morbidity and mortality. High-affinity neutralizing antibody is important for controlling infection, which is closely regulated by follicular helper T (Tfh) cells. Tfh cells play a central role in promoting germinal center reactions and driving cognate B cell differentiation for antibody secretion. Available studies indicate a close relationship between virus-specific Tfh cell-mediated immunity and SARS-CoV-2 infection progression. Although several lines of evidence have suggested that Tfh cells contribute to the control of SARS-CoV-2 infection by eliciting neutralizing antibody productions, further studies are needed to elucidate Tfh-mediated effector mechanisms in anti-SARS-CoV-2 immunity. Here, we summarize the functional features and roles of virus-specific Tfh cells in the immunopathogenesis of SARS-CoV-2 infection and in COVID-19 vaccines, and highlight the potential of targeting Tfh cells as therapeutic strategy against SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / T Follicular Helper Cells / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.731100

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / T Follicular Helper Cells / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.731100