SARS-CoV-2-Reactive Mucosal B Cells in the Upper Respiratory Tract of Uninfected Individuals.
J Immunol
; 207(10): 2581-2588, 2021 11 15.
Article
in English
| MEDLINE | ID: covidwho-1450886
ABSTRACT
SARS-CoV-2 is a respiratory pathogen that can cause severe disease in at-risk populations but results in asymptomatic infections or a mild course of disease in the majority of cases. We report the identification of SARS-CoV-2-reactive B cells in human tonsillar tissue obtained from children who were negative for coronavirus disease 2019 prior to the pandemic and the generation of mAbs recognizing the SARS-CoV-2 Spike protein from these B cells. These Abs showed reduced binding to Spike proteins of SARS-CoV-2 variants and did not recognize Spike proteins of endemic coronaviruses, but subsets reacted with commensal microbiota and exhibited SARS-CoV-2-neutralizing potential. Our study demonstrates pre-existing SARS-CoV-2-reactive Abs in various B cell populations in the upper respiratory tract lymphoid tissue that may lead to the rapid engagement of the pathogen and contribute to prevent manifestations of symptomatic or severe disease.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory System
/
B-Lymphocytes
/
Receptors, Antigen, B-Cell
/
Adenoids
/
B-Lymphocyte Subsets
/
SARS-CoV-2
/
COVID-19
/
Mucous Membrane
Type of study:
Prognostic study
Topics:
Variants
Limits:
Child
/
Humans
Language:
English
Journal:
J Immunol
Year:
2021
Document Type:
Article
Affiliation country:
Jimmunol.2100606
Similar
MEDLINE
...
LILACS
LIS