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Fatigue in post-acute sequelae of SARS-CoV2 (PASC) treated with oxygen-ozone autohemotherapy - preliminary results on 100 patients.
Tirelli, U; Franzini, M; Valdenassi, L; Pisconti, S; Taibi, R; Torrisi, C; Pandolfi, S; Chirumbolo, S.
  • Tirelli U; Tirelli Medical Group, Pordenone, Italy. salvatore.chirumbolo@univr.it.
Eur Rev Med Pharmacol Sci ; 25(18): 5871-5875, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1451046
ABSTRACT

OBJECTIVE:

Post-acute sequelae of SARS-CoV2 infection (PASC) are a novel terminology used to describe post-COVID persistent symptoms, mimicking somehow the previously described chronic fatigue syndrome (CFS). In this manuscript, we evaluated a therapeutical approach to address PASC-derived fatigue in a cohort of past-COVID-19 positive patients. PATIENTS AND

METHODS:

A number of 100 patients, previously diagnosed as COVID-19 positive subjects and meeting our eligibility criteria, was diagnosed having PASC-related fatigue. They were recruited in the study and treated with oxygen-ozone autohemotherapy (O2-O3-AHT), according to the SIOOT protocol. Patients' response to O2-O3-AHT and changes in fatigue were measured with the 7-scoring Fatigue Severity Scale (FSS), according to previously published protocols.

RESULTS:

Statistics assessed that the effects of O2-O3-AHT on fatigue reduced PASC symptoms by 67%, as a mean, in all the investigated cohort of patients (H = 148.4786 p < 0.0001) (Figure 1). Patients following O2-O3-AHT therapy, quite completely recovered for PASC-associated fatigue, a quote amounting to about two fifths (around 40%) of the whole cohort undergoing ozone treatment and despite most of patients were female subjects, the effect was not influenced by sex distribution (H = 0.7353, p = 0.39117).

CONCLUSIONS:

Ozone therapy is able to recover normal functionality and to relief pain and discomfort in the form of PASC-associated fatigue in at least 67% of patients suffering from post-COVID sequelae, aside from sex and age distribution.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Oxygen / Ozone / Blood Transfusion / Fatigue Syndrome, Chronic / COVID-19 Subject: Oxygen / Ozone / Blood Transfusion / Fatigue Syndrome, Chronic / COVID-19 Type of study: Controlled clinical trial Language: English Journal: Eur Rev Med Pharmacol Sci Clinical aspect: Etiology / Therapy Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Oxygen / Ozone / Blood Transfusion / Fatigue Syndrome, Chronic / COVID-19 Subject: Oxygen / Ozone / Blood Transfusion / Fatigue Syndrome, Chronic / COVID-19 Type of study: Controlled clinical trial Language: English Journal: Eur Rev Med Pharmacol Sci Clinical aspect: Etiology / Therapy Year: 2021
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