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Immunological response against SARS-CoV-2 following full-dose administration of Comirnaty® COVID-19 vaccine in nursing home residents.
Albert, Eliseo; Burgos, Javier S; Peiró, Salvador; Salas, Dolores; Vanaclocha, Hermelinda; Giménez, Estela; Limón, Ramón; Alcaraz, María Jesús; Sánchez-Payá, José; Díez-Domingo, Javier; Navarro, David.
  • Albert E; Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
  • Burgos JS; General Directorate of Research and Healthcare Supervision, Department of Health, Valencia Government, Valencia, Spain.
  • Peiró S; Foundation for the Promotion of Health and Biomedical Research of the Valencian Community (FISABIO), Valencia, Spain.
  • Salas D; Foundation for the Promotion of Health and Biomedical Research of the Valencian Community (FISABIO), Valencia, Spain; General Directorate of Public Health, Department of Health, Valencia Government, Valencia, Spain.
  • Vanaclocha H; General Directorate of Public Health, Department of Health, Valencia Government, Valencia, Spain.
  • Giménez E; Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
  • Limón R; General Directorate of Healthcare. Department of Health, Valencia Government, Valencia, Spain.
  • Alcaraz MJ; Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
  • Sánchez-Payá J; Preventive Medicine Service, Alicante General and University Hospital, Alicante, Spain; Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain.
  • Díez-Domingo J; Foundation for the Promotion of Health and Biomedical Research of the Valencian Community (FISABIO), Valencia, Spain.
  • Navarro D; Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain; Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain. Electronic address: david.navarro@uv.es.
Clin Microbiol Infect ; 28(2): 279-284, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1454099
ABSTRACT

OBJECTIVES:

The current study was aimed at examining SARS-CoV-2 immune responses following two doses of Comirnaty® COVID-19 vaccine among elderly people in nursing homes.

METHODS:

A prospective cohort study in a representative sample from nursing homes in Valencia (n = 881; males 271, females 610; median age, 86 years) recruited residents using a random one-stage cluster sampling approach. A lateral flow immunochromatography device (LFIC) (OnSite COVID-19 IgG/IgM Rapid Test; CTK BIOTECH, Poway, CA, USA) was used as the front-line test for detecting SARS-CoV-2-Spike (S)-specific antibodies in whole blood obtained using a fingerstick. Residents returning negative LFIC results underwent venipuncture and testing for presence of SARS-CoV-2-S-reactive antibodies and T cells using the Roche Elecsys® Anti-SARS-CoV-2 S (Roche Diagnostics, Pleasanton, CA, USA), the LIAISON® SARS-CoV-2 TrimericS IgG assay (Diasorin S.p.A, Saluggia, Italy) and by flow cytometry, respectively.

RESULTS:

The SARS-CoV-2-S antibody detection rate in nursing home residents was 99.6% (283/284) and 98.3% (587/597) for SARS-CoV-2 recovered and naïve residents, respectively, within a median of 99 days (range 17-125 days) after full vaccination. Three out of five residents lacking SARS-CoV-2-S antibodies had detectable S-reactive CD8+ and/or CD4+ T cells. In addition, 50/50 and 40/50 participants with detectable SARS-CoV-2 antibodies also had SARS-CoV-2-S-reactive interferon-γ-producing CD4+ and CD8+ T cells, respectively.

DISCUSSION:

The Comirnaty® COVID-19 vaccine is highly immunogenic in nursing home residents.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Aged / Female / Humans / Male Language: English Journal: Clin Microbiol Infect Journal subject: Communicable Diseases / Microbiology Year: 2022 Document Type: Article Affiliation country: J.cmi.2021.09.031

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Aged / Female / Humans / Male Language: English Journal: Clin Microbiol Infect Journal subject: Communicable Diseases / Microbiology Year: 2022 Document Type: Article Affiliation country: J.cmi.2021.09.031