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Real-world evidence for the effectiveness and breakthrough of BNT162b2 mRNA COVID-19 vaccine at a medical center in Japan.
Naito, Toshio; Yan, Yan; Tabe, Yoko; Seyama, Kuniaki; Deshpande, Gautam A.
  • Naito T; Department of General Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Yan Y; Department of Palliative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Tabe Y; Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Seyama K; Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Deshpande GA; Department of General Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Hum Vaccin Immunother ; 18(1): 1-2, 2022 Dec 31.
Article in English | MEDLINE | ID: covidwho-1455134
ABSTRACT
Evidence of BNT126b2 vaccine effectiveness and breakthrough has been primarily demonstrated in populations outside of Asia; studies in the Western Pacific region are limited. Our retrospective cohort study assessed SARS-CoV-2 cases after vaccine rollout starting from mid-March 2021 at a tertiary hospital in Tokyo. Of 8,749 staff members, no fully vaccinated staff demonstrated confirmed infection, versus 19 cases in unvaccinated or partially vaccinated staff, by the end of June. Three breakthrough cases were identified in July, correlating with spread of delta variant in Tokyo. While our findings confirm the effectiveness of BNT162b2 vaccine in Asian populations, the presence of breakthrough cases despite strict infection control regulations suggest that ongoing public hygiene measures are required even after vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / BNT162 Vaccine Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: Asia Language: English Journal: Hum Vaccin Immunother Year: 2022 Document Type: Article Affiliation country: 21645515.2021.1984124

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / BNT162 Vaccine Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: Asia Language: English Journal: Hum Vaccin Immunother Year: 2022 Document Type: Article Affiliation country: 21645515.2021.1984124