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Association between Body Mass Index and Risk of Coronavirus Disease 2019 (COVID-19): A Nationwide Case-control Study in South Korea.
Jung, Chan-Young; Park, Haeyong; Kim, Dong Wook; Lim, Hyunsun; Chang, Jung Hyun; Choi, Yoon Jung; Kim, Seong Woo; Chang, Tae Ik.
  • Jung CY; Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyangshi, Gyeonggi-do, Republic of Korea.
  • Park H; Research and Analysis Team, National Health Insurance Service Ilsan Hospital, Goyangshi, Gyeonggi-do, Republic of Korea.
  • Kim DW; Department of Big Data, National Health Insurance Service, Wonju-si, Gangwon-do, Republic of Korea.
  • Lim H; Research and Analysis Team, National Health Insurance Service Ilsan Hospital, Goyangshi, Gyeonggi-do, Republic of Korea.
  • Chang JH; Department of Otorhinolaryngology, National Health Insurance Service Ilsan Hospital, Goyangshi, Gyeonggi-do, Republic of Korea.
  • Choi YJ; Department of Pathology, National Health Insurance Service Ilsan Hospital, Goyangshi, Gyeonggi-do, Republic of Korea.
  • Kim SW; Department of Physical Medicine and Rehabilitation, National Health Insurance Service Ilsan Hospital, Goyangshi, Gyeonggi-do, Republic of Korea.
  • Chang TI; Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyangshi, Gyeonggi-do, Republic of Korea.
Clin Infect Dis ; 73(7): e1855-e1862, 2021 10 05.
Article in English | MEDLINE | ID: covidwho-1455257
Semantic information from SemMedBD (by NLM)
1. Obesity PREDISPOSES COVID-19
Subject
Obesity
Predicate
PREDISPOSES
Object
COVID-19
2. Body mass index procedure DIAGNOSES COVID-19
Subject
Body mass index procedure
Predicate
DIAGNOSES
Object
COVID-19
3. Obesity PROCESS_OF Persons
Subject
Obesity
Predicate
PROCESS_OF
Object
Persons
4. Normal weight PROCESS_OF Persons
Subject
Normal weight
Predicate
PROCESS_OF
Object
Persons
5. ORALIT TREATS Obesity
Subject
ORALIT
Predicate
TREATS
Object
Obesity
6. ORALIT TREATS Overweight
Subject
ORALIT
Predicate
TREATS
Object
Overweight
7. Obesity PREDISPOSES COVID-19
Subject
Obesity
Predicate
PREDISPOSES
Object
COVID-19
8. Body mass index procedure DIAGNOSES COVID-19
Subject
Body mass index procedure
Predicate
DIAGNOSES
Object
COVID-19
9. Obesity PROCESS_OF Persons
Subject
Obesity
Predicate
PROCESS_OF
Object
Persons
10. Normal weight PROCESS_OF Persons
Subject
Normal weight
Predicate
PROCESS_OF
Object
Persons
11. ORALIT TREATS Obesity
Subject
ORALIT
Predicate
TREATS
Object
Obesity
12. ORALIT TREATS Overweight
Subject
ORALIT
Predicate
TREATS
Object
Overweight
ABSTRACT

BACKGROUND:

Increased body mass index (BMI) has been associated with a higher risk of severe coronavirus disease 2019 (COVID-19) infections. However, whether obesity is a risk factor for contracting COVID-19 has hardly been investigated so far.

METHODS:

We examined the association between BMI level and the risk of COVID-19 infection in a nationwide case-control study comprised of 3788 case patients confirmed to have COVID-19 between 24 January and 9 April 2020 and 15 152 controls matched by age and sex, who were aged 20 years or more and underwent National Health Insurance Service (NHIS) health examinations between 2015-2017, using data from the Korean NHIS with linkage to the Korea Centers for Disease Control and Prevention data. Our primary exposure of interest was BMI level, categorized into 4 groups <18.5 (underweight), 18.5-22.9 (normal weight), 23-24.9 (overweight), and ≥25 kg/m2 (obese).

RESULTS:

Of the entire 18 940 study participants, 11 755 (62.1%) were women, and the mean age of the study participants was 53.7 years (standard deviation, 13.8). In multivariable logistic regression models adjusted for sociodemographic, comorbidity, laboratory, and medication data, there was a graded association between higher BMI levels and higher risk of COVID-19 infection. Compared to normal-weight individuals, the adjusted odds ratios in the overweight and obese individuals were 1.13 (95% confidence interval [CI], 1.03-1.25) and 1.26 (95% CI, 1.15-1.39), respectively. This association was robust across age and sex subgroups.

CONCLUSIONS:

Higher BMI levels were associated with a higher risk of contracting COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Etiology study / Observational study / Prognostic study / Randomized controlled trials / Risk factors Limits: Adult / Female / Humans / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Etiology study / Observational study / Prognostic study / Randomized controlled trials / Risk factors Limits: Adult / Female / Humans / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article