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Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019.
Martinot, Martin; Jary, Aude; Fafi-Kremer, Samira; Leducq, Valentin; Delagreverie, Heloise; Garnier, Marc; Pacanowski, Jérôme; Mékinian, Arsène; Pirenne, France; Tiberghien, Pierre; Calvez, Vincent; Humbrecht, Catherine; Marcelin, Anne-Geneviève; Lacombe, Karine.
  • Martinot M; Infectious Diseases Department, Hôpitaux Civils de Colmar, Colmar, France.
  • Jary A; Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Pitié-Salpêtrière Hospital, Department of Virology, Paris, France.
  • Fafi-Kremer S; Virology Laboratory, Strasbourg University Hospital, Strasbourg, France.
  • Leducq V; Strasbourg University, INSERM, IRM UMR-S 1109, F-67000 Strasbourg, France.
  • Delagreverie H; Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Pitié-Salpêtrière Hospital, Department of Virology, Paris, France.
  • Garnier M; Virology Laboratory, Strasbourg University Hospital, Strasbourg, France.
  • Pacanowski J; Strasbourg University, INSERM, IRM UMR-S 1109, F-67000 Strasbourg, France.
  • Mékinian A; Sorbonne Université, GRC 29, APHP, DMU DREAM, Anesthesiology and Intensive Care Department, Saint-Antoine Hospital, Paris, France.
  • Pirenne F; Infectious Diseases Department, Saint-Antoine Hospital, APHP - Sorbonne Université, Paris, France.
  • Tiberghien P; Sorbonne Université, Internal Medicine Department, Inflammation-Immunopathology-Biotherapy Department (DMU i3D), Saint-Antoine Hospital, AP-HP, Paris, France.
  • Calvez V; Etablissement Français du Sang, La Plaine St-Denis - France.
  • Humbrecht C; Institut Mondor de Recherche Biomédicale, Unité 955, Equipe 2: Transfusion et Maladies du Globule Rouge, INSERM, EFS, Université Paris-Est Créteil, Créteil, France.
  • Marcelin AG; Etablissement Français du Sang, La Plaine St-Denis - France.
  • Lacombe K; UMR 1098 RIGHT Inserm Université de Franche-Comté Etablissement Français du Sang, Besançon.
Clin Infect Dis ; 73(7): e1762-e1765, 2021 10 05.
Article in English | MEDLINE | ID: covidwho-1455264
Semantic information from SemMedBD (by NLM)
1. RNA-Directed RNA Polymerase PART_OF 2019 novel coronavirus
Subject
RNA-Directed RNA Polymerase
Predicate
PART_OF
Object
2019 novel coronavirus
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Patients LOCATION_OF RNA-Directed RNA Polymerase
Subject
Patients
Predicate
LOCATION_OF
Object
RNA-Directed RNA Polymerase
4. 2019 novel coronavirus PROCESS_OF Patients
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Patients
5. Immunologic Deficiency Syndromes PROCESS_OF Woman
Subject
Immunologic Deficiency Syndromes
Predicate
PROCESS_OF
Object
Woman
6. Mutation ASSOCIATED_WITH RNA-directed RNA polymerase activity
Subject
Mutation
Predicate
ASSOCIATED_WITH
Object
RNA-directed RNA polymerase activity
7. Persistent viremia PROCESS_OF Woman
Subject
Persistent viremia
Predicate
PROCESS_OF
Object
Woman
8. Mutation PROCESS_OF Woman
Subject
Mutation
Predicate
PROCESS_OF
Object
Woman
9. RNA-Directed RNA Polymerase PART_OF 2019 novel coronavirus
Subject
RNA-Directed RNA Polymerase
Predicate
PART_OF
Object
2019 novel coronavirus
10. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
11. Patients LOCATION_OF RNA-Directed RNA Polymerase
Subject
Patients
Predicate
LOCATION_OF
Object
RNA-Directed RNA Polymerase
12. 2019 novel coronavirus PROCESS_OF Patients
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Patients
13. Immunologic Deficiency Syndromes PROCESS_OF Woman
Subject
Immunologic Deficiency Syndromes
Predicate
PROCESS_OF
Object
Woman
14. Mutation ASSOCIATED_WITH RNA-directed RNA polymerase activity
Subject
Mutation
Predicate
ASSOCIATED_WITH
Object
RNA-directed RNA polymerase activity
15. Persistent viremia PROCESS_OF Woman
Subject
Persistent viremia
Predicate
PROCESS_OF
Object
Woman
16. Mutation PROCESS_OF Woman
Subject
Mutation
Predicate
PROCESS_OF
Object
Woman
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered virus for which remdesivir is the only antiviral available. We report the occurrence of a mutation in RdRP (D484Y) following treatment with remdesivir in a 76-year-old female with post-rituximab B-cell immunodeficiency and persistent SARS-CoV-2 viremia. A cure was achieved after supplementation with convalescent plasma.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: RNA-Dependent RNA Polymerase / COVID-19 Subject: RNA-Dependent RNA Polymerase / COVID-19 Type of study: Case report Language: English Journal: Clin Infect Dis Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: RNA-Dependent RNA Polymerase / COVID-19 Subject: RNA-Dependent RNA Polymerase / COVID-19 Type of study: Case report Language: English Journal: Clin Infect Dis Year: 2021
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