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Bioaerosol Sampling for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a Referral Center with Critically Ill Coronavirus Disease 2019 (COVID-19) Patients March-May 2020.
Lane, Morgan A; Brownsword, Erik A; Babiker, Ahmed; Ingersoll, Jessica M; Waggoner, Jesse; Ayers, Marie; Klopman, Matthew; Uyeki, Timothy M; Lindsley, William G; Kraft, Colleen S.
  • Lane MA; Division of Infectious Diseases, Department of Medicine, Emory University, Atlanta, Georgia, USA.
  • Brownsword EA; Division of Infectious Diseases, Department of Medicine, Emory University, Atlanta, Georgia, USA.
  • Babiker A; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.
  • Ingersoll JM; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA.
  • Waggoner J; Division of Infectious Diseases, Department of Medicine, Emory University, Atlanta, Georgia, USA.
  • Ayers M; Emory Healthcare, Atlanta, Georgia, USA.
  • Klopman M; Emory Healthcare, Atlanta, Georgia, USA.
  • Uyeki TM; Emory Healthcare, Atlanta, Georgia, USA.
  • Lindsley WG; Department of Anesthesiology, Emory University, Atlanta, Georgia, USA.
  • Kraft CS; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Clin Infect Dis ; 73(7): e1790-e1794, 2021 10 05.
Article in English | MEDLINE | ID: covidwho-1455276
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Nucleocapsid PART_OF 2019 novel coronavirus
Subject
Nucleocapsid
Predicate
PART_OF
Object
2019 novel coronavirus
3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
4. Nucleocapsid PART_OF 2019 novel coronavirus
Subject
Nucleocapsid
Predicate
PART_OF
Object
2019 novel coronavirus
ABSTRACT

BACKGROUND:

Previous research has shown that rooms of patients with coronavirus disease 2019 (COVID-19) present the potential for healthcare-associated transmission through aerosols containing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, data on the presence of these aerosols outside of patient rooms are limited. We investigated whether virus-containing aerosols were present in nursing stations and patient room hallways in a referral center with critically ill COVID-19 patients.

METHODS:

Eight National Institute for Occupational Safety and Health BC 251 2-stage cyclone samplers were set up throughout 6 units, including nursing stations and visitor corridors in intensive care units and general medical units, for 6 h each sampling period. Samplers were placed on tripods which held 2 samplers positioned 102 cm and 152 cm above the floor. Units were sampled for 3 days. Extracted samples underwent reverse transcription polymerase chain reaction for selected gene regions of the SARS-CoV-2 virus nucleocapsid and the housekeeping gene human RNase P as an internal control.

RESULTS:

The units sampled varied in the number of laboratory-confirmed COVID-19 patients present on the days of sampling. Some of the units included patient rooms under negative pressure, while most were maintained at a neutral pressure. Of 528 aerosol samples collected, none were positive for SARS-CoV-2 RNA by the estimated limit of detection of 8 viral copies/m3 of air.

CONCLUSIONS:

Aerosolized SARS-CoV-2 outside of patient rooms was undetectable. While healthcare personnel should avoid unmasked close contact with each other, these findings may provide reassurance for the use of alternatives to tight-fitting respirators in areas outside of patient rooms during the current pandemic.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Limits: Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Limits: Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid