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Ketamine for post-operative pain treatment in spinal surgery. A protocol for a systematic review with meta-analysis and trial sequential analysis.
Pind, Alison Holten; Laursen, Christina Cleveland; Andersen, Cheme; Maagaard, Mathias; Mathiesen, Ole.
  • Pind AH; Department of Anaesthesiology, Centre for Anaesthesiological Research, Zealand University Hospital, Koege, Denmark.
  • Laursen CC; Department of Anaesthesiology, Centre for Anaesthesiological Research, Zealand University Hospital, Koege, Denmark.
  • Andersen C; Department of Anaesthesiology, Centre for Anaesthesiological Research, Zealand University Hospital, Koege, Denmark.
  • Maagaard M; Department of Anaesthesiology, Centre for Anaesthesiological Research, Zealand University Hospital, Koege, Denmark.
  • Mathiesen O; Department of Anaesthesiology, Centre for Anaesthesiological Research, Zealand University Hospital, Koege, Denmark.
Acta Anaesthesiol Scand ; 65(1): 128-134, 2021 01.
Article in English | MEDLINE | ID: covidwho-1455487
Semantic information from SemMedBD (by NLM)
1. ketamine TREATS Pai
Subject
ketamine
Predicate
TREATS
Object
Pai
2. Operative procedure on spine TREATS Patients
Subject
Operative procedure on spine
Predicate
TREATS
Object
Patients
3. ketamine TREATS Patients
Subject
ketamine
Predicate
TREATS
Object
Patients
4. Pain management USES ketamine
Subject
Pain management
Predicate
USES
Object
ketamine
5. Placebos NEG_TREATS Patients
Subject
Placebos
Predicate
NEG_TREATS
Object
Patients
6. Interventional procedure NEG_TREATS Patients
Subject
Interventional procedure
Predicate
NEG_TREATS
Object
Patients
7. ketamine TREATS Pain, Postoperative
Subject
ketamine
Predicate
TREATS
Object
Pain, Postoperative
8. Operative procedure on spine TREATS Patients
Subject
Operative procedure on spine
Predicate
TREATS
Object
Patients
9. ketamine TREATS Patients
Subject
ketamine
Predicate
TREATS
Object
Patients
10. Pain management USES ketamine
Subject
Pain management
Predicate
USES
Object
ketamine
11. Placebos NEG_TREATS Patients
Subject
Placebos
Predicate
NEG_TREATS
Object
Patients
12. Interventional procedure NEG_TREATS Patients
Subject
Interventional procedure
Predicate
NEG_TREATS
Object
Patients
ABSTRACT

BACKGROUND:

Post-operative pain treatment with ketamine has been demonstrated to have post-operative opioid-sparing and anti-hyperalgesic effects. However, evidence regarding the beneficial and harmful effects and the optimal dose and timing of perioperative treatment with ketamine for patients undergoing spinal surgery is unclear. The objective of this systematic review is to assess the analgesic, serious and non-serious adverse effects of perioperative pain treatment with ketamine for patients undergoing spinal surgery.

METHODS:

This protocol for a systematic review is written according to The Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines. We will search Embase, CENTRAL, PubMed, WHO's ICTRP, EU Clinical Trial Register and ClinicalTrials.gov to identify relevant randomised clinical trials. We will include all randomised clinical trials assessing perioperative ketamine treatment versus placebo or no intervention for patients undergoing spinal surgery. Two authors will independently screen trials for inclusion using Covidence, extract data and assess risk of bias using Cochrane's RoB tool. We will analyse data using Review Manager and Trial Sequential Analysis. Meta-analysis will be performed according to the Cochrane guidelines and results will be validated according to the eight-step procedure suggested by Jakobsen et al. We will present our primary findings in a 'summary of findings' table. We will evaluate the overall certainty of evidence using the GRADE approach.

DISCUSSION:

This systematic review will assess the beneficial and harmful effects of perioperative pain treatment with ketamine for patients undergoing spinal surgery and have the potential to inform best practice and advance research.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Ketamine Type of study: Controlled clinical trial / Clinical Practice Guide / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: Acta Anaesthesiol Scand Year: 2021 Document Type: Article Affiliation country: Aas.13712

Full text: Available Collection: International databases Database: MEDLINE Main subject: Ketamine Type of study: Controlled clinical trial / Clinical Practice Guide / Prognostic study / Randomized controlled trials / Reviews Limits: Humans Language: English Journal: Acta Anaesthesiol Scand Year: 2021 Document Type: Article Affiliation country: Aas.13712