Effect of paternal health on pregnancy loss-A review of current evidence.
Andrologia
; 54(1): e14259, 2022 Feb.
Article
in English
| MEDLINE | ID: covidwho-1455503
ABSTRACT
Pregnancy loss has multifactorial causes, and the maternal risk factors are the most investigated. Therefore, this review investigates the current literature regarding the effect of paternal health on pregnancy loss. This review is conducted according to the PRISMA guidelines. The electronic databases PubMed and Medline were the primary sources of information. The online tool covidence.org was used for the screening process. The Newcastle-Ottawa Scale was used for assessment of risk of bias across the non-RCT (Randomized Controlled Trials) included studies. Six cohort studies and one randomised clinical trial were included for assessment in this review. Especially three large retrospective studies reported that circulatory paternal health issue, increasing metabolic syndrome diagnoses and paternal age was significantly associated with a higher risk of pregnancy loss. Lower pregnancy loss was also found in couples with diabetes in the man compared to couples without diabetes. One study suggests a connection between varicocelectomy and improved sperm DNA fragmentation and lower abortion rate. This review confirms that paternal age, somatic health and particularly health regarding cardiovascular and metabolic disease are associated positively with risks of pregnancy loss. However, further research may lead to evidence, which are more conclusive.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Abortion, Spontaneous
/
Abortion, Induced
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
Limits:
Female
/
Humans
/
Male
/
Pregnancy
Language:
English
Journal:
Andrologia
Year:
2022
Document Type:
Article
Affiliation country:
And.14259
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