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Impact of cardiac rehabilitation on mortality and morbidity in diabetic versus non-diabetic patients: protocol for a systematic review and meta-analysis.
Dababneh, Emad Hanna; Saha, Sumanta; Östlundh, Linda; Al-Rifai, Rami H; Oulhaj, Abderrahim.
  • Dababneh EH; Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE.
  • Saha S; Academic Affairs, Tawam Hospital, Al Ain, UAE.
  • Östlundh L; R. G. Kar Medical College, Kolkata, West Bengal, India.
  • Al-Rifai RH; National Medical Library, United Arab Emirates University College of Medicine and Health Sciences, Al Ain, Abu Dhabi, UAE.
  • Oulhaj A; Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE.
BMJ Open ; 11(4): e047134, 2021 04 13.
Article in English | MEDLINE | ID: covidwho-1455715
Semantic information from SemMedBD (by NLM)
1. Cardiac rehabilitation TREATS diabetic
Subject
Cardiac rehabilitation
Predicate
TREATS
Object
diabetic
2. Cardiac rehabilitation AFFECTS Patients
Subject
Cardiac rehabilitation
Predicate
AFFECTS
Object
Patients
3. Heart Diseases PROCESS_OF Patients
Subject
Heart Diseases
Predicate
PROCESS_OF
Object
Patients
4. Cardiac rehabilitation TREATS Diabetes Mellitu
Subject
Cardiac rehabilitation
Predicate
TREATS
Object
Diabetes Mellitu
5. Diabetes Mellitu PROCESS_OF C0030705
Subject
Diabetes Mellitu
Predicate
PROCESS_OF
Object
C0030705
6. Cardiac rehabilitation TREATS Patients
Subject
Cardiac rehabilitation
Predicate
TREATS
Object
Patients
7. Heart Diseases PROCESS_OF Adult
Subject
Heart Diseases
Predicate
PROCESS_OF
Object
Adult
8. Myocardial Infarction PROCESS_OF Adult
Subject
Myocardial Infarction
Predicate
PROCESS_OF
Object
Adult
9. Cardiac rehabilitation TREATS diabetic
Subject
Cardiac rehabilitation
Predicate
TREATS
Object
diabetic
10. Cardiac rehabilitation AFFECTS Patients
Subject
Cardiac rehabilitation
Predicate
AFFECTS
Object
Patients
11. Heart Diseases PROCESS_OF Patients
Subject
Heart Diseases
Predicate
PROCESS_OF
Object
Patients
12. Cardiac rehabilitation TREATS Diabetes Mellitus, Non-Insulin-Dependent
Subject
Cardiac rehabilitation
Predicate
TREATS
Object
Diabetes Mellitus, Non-Insulin-Dependent
13. Diabetes Mellitus, Non-Insulin-Dependent PROCESS_OF Patients
Subject
Diabetes Mellitus, Non-Insulin-Dependent
Predicate
PROCESS_OF
Object
Patients
14. Cardiac rehabilitation TREATS Patients
Subject
Cardiac rehabilitation
Predicate
TREATS
Object
Patients
15. Heart Diseases PROCESS_OF Adult
Subject
Heart Diseases
Predicate
PROCESS_OF
Object
Adult
16. Myocardial Infarction PROCESS_OF Adult
Subject
Myocardial Infarction
Predicate
PROCESS_OF
Object
Adult
ABSTRACT

BACKGROUND:

Cardiac rehabilitation (CR) decreases the morbidity and mortality risk among patients with cardiac diseases; however, the impact of CR on patients with diabetes remains underexplored. This is a protocol for a systematic review and meta-analysis methodology to explore if the effect of CR on mortality and morbidity is the same in patients with type 2 diabetes compared with patients without diabetes. METHODS AND

ANALYSIS:

Interventional and non-interventional studies comparing the effect of CR, for at least 1 month, on all-cause mortality and cardiovascular outcomes including fatal and non-fatal myocardial infarction, revascularisation and rehospitalisation in adults with cardiac diseases will be deemed eligible for inclusion. Studies published between 1990 and 2020 will be searched in PubMed, Embase, Cochrane, CINAHL, Scopus and in registries for randomised controlled trials. Eligible studies will be selected using the Covidence software, and their salient details regarding the design, population, tested interventions and outcomes of interest will be gathered. The quality of studies to be deemed eligible and reviewed will be assessed using the Cochrane Collaboration and National Heart, Lung, and Blood Institute's tools. The appraisal process will be based on the study design (interventional and non-interventional). In the meta-analysis step, the pooled effect of CR on the outcomes will be estimated. All meta-analyses will be done using the random-effects model approach (inverse-variance method). I 2 and p value of χ2 statistics will guide the heterogeneity assessment. Subgroup analyses will also be performed. The small study effect will be investigated by generating the funnel plots. The symmetry of the latter will be tested by performing Egger's test. ETHICS AND DISSEMINATION The systematic review will use data from published literature; hence, no ethical approval will be required. Findings of the systematic review and meta-analysis will be published in peer-reviewed international journals and will be disseminated in local and international scientific meetings. PROSPERO REGISTRATION NUMBER CRD42020148832.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Diabetes Mellitus, Type 2 / Cardiac Rehabilitation / Myocardial Infarction Subject: Diabetes Mellitus, Type 2 / Cardiac Rehabilitation / Myocardial Infarction Type of study: Controlled clinical trial / Ethical aspects / Prognostic study Language: English Journal: BMJ Open Clinical aspect: Etiology Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Diabetes Mellitus, Type 2 / Cardiac Rehabilitation / Myocardial Infarction Subject: Diabetes Mellitus, Type 2 / Cardiac Rehabilitation / Myocardial Infarction Type of study: Controlled clinical trial / Ethical aspects / Prognostic study Language: English Journal: BMJ Open Clinical aspect: Etiology Year: 2021
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