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Pharmacologic Activities of Plant-Derived Natural Products on Respiratory Diseases and Inflammations.
Timalsina, Deepak; Pokhrel, Krishna Prasad; Bhusal, Deepti.
  • Timalsina D; Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu 44618, Nepal.
  • Pokhrel KP; Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu 44618, Nepal.
  • Bhusal D; Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu 44618, Nepal.
Biomed Res Int ; 2021: 1636816, 2021.
Article in English | MEDLINE | ID: covidwho-1455769
ABSTRACT
Respiratory inflammation is caused by an air-mediated disease induced by polluted air, smoke, bacteria, and viruses. The COVID-19 pandemic is also a kind of respiratory disease, induced by a virus causing a serious effect on the lungs, bronchioles, and pharynges that results in oxygen deficiency. Extensive research has been conducted to find out the potent natural products that help to prevent, treat, and manage respiratory diseases. Traditionally, wider floras were reported to be used, such as Morus alba, Artemisia indica, Azadirachta indica, Calotropis gigantea, but only some of the potent compounds from some of the plants have been scientifically validated. Plant-derived natural products such as colchicine, zingerone, forsythiaside A, mangiferin, glycyrrhizin, curcumin, and many other compounds are found to have a promising effect on treating and managing respiratory inflammation. In this review, current clinically approved drugs along with the efficacy and side effects have been studied. The study also focuses on the traditional uses of medicinal plants on reducing respiratory complications and their bioactive phytoconstituents. The pharmacological evidence of lowering respiratory complications by plant-derived natural products has been critically studied with detailed mechanism and action. However, the scientific validation of such compounds requires clinical study and evidence on animal and human models to replace modern commercial medicine.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plants, Medicinal / Plant Extracts / Pandemics / Phytochemicals / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment Type of study: Observational study / Prognostic study Topics: Traditional medicine Limits: Animals / Humans Language: English Journal: Biomed Res Int Year: 2021 Document Type: Article Affiliation country: 2021

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plants, Medicinal / Plant Extracts / Pandemics / Phytochemicals / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment Type of study: Observational study / Prognostic study Topics: Traditional medicine Limits: Animals / Humans Language: English Journal: Biomed Res Int Year: 2021 Document Type: Article Affiliation country: 2021