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Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview.
Vyavahare, Sagar; Kumar, Sandeep; Cantu, Nicholas; Kolhe, Ravindra; Bollag, Wendy B; McGee-Lawrence, Meghan E; Hill, William D; Hamrick, Mark W; Isales, Carlos M; Fulzele, Sadanand.
  • Vyavahare S; Department of Cell Biology and Anatomy, Augusta University, Augusta, GA, USA.
  • Kumar S; Department of Cell Biology and Anatomy, Augusta University, Augusta, GA, USA.
  • Cantu N; Department of Medicine, Augusta University, Augusta, GA, USA.
  • Kolhe R; Department of Pathology, Augusta University, Augusta, GA, USA.
  • Bollag WB; Department of Physiology, Augusta University, Augusta, GA, USA.
  • McGee-Lawrence ME; Center for Healthy Aging, Augusta University, Augusta, GA, USA.
  • Hill WD; Department of Cell Biology and Anatomy, Augusta University, Augusta, GA, USA.
  • Hamrick MW; Center for Healthy Aging, Augusta University, Augusta, GA, USA.
  • Isales CM; Department of Pathology, Medical University of South Carolina, Charleston, SC, USA.
  • Fulzele S; Department of Cell Biology and Anatomy, Augusta University, Augusta, GA, USA.
Mediators Inflamm ; 2021: 2911578, 2021.
Article in English | MEDLINE | ID: covidwho-1455770
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), affecting multiple organ systems, including the respiratory tract and lungs. Several studies have reported that the tryptophan-kynurenine pathway is altered in COVID-19 patients. The tryptophan-kynurenine pathway plays a vital role in regulating inflammation, metabolism, immune responses, and musculoskeletal system biology. In this minireview, we surmise the effects of the kynurenine pathway in COVID-19 patients and how this pathway might impact muscle and bone biology.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tryptophan / Bone Diseases / SARS-CoV-2 / COVID-19 / Kynurenine / Muscular Diseases Topics: Long Covid Limits: Animals / Humans Language: English Journal: Mediators Inflamm Journal subject: Biochemistry / Pathology Year: 2021 Document Type: Article Affiliation country: 2021

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tryptophan / Bone Diseases / SARS-CoV-2 / COVID-19 / Kynurenine / Muscular Diseases Topics: Long Covid Limits: Animals / Humans Language: English Journal: Mediators Inflamm Journal subject: Biochemistry / Pathology Year: 2021 Document Type: Article Affiliation country: 2021