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The promising use of nano-molecular imprinted templates for improved SARS-CoV-2 detection, drug delivery and research.
Nahhas, Alaa F; Webster, Thomas J.
  • Nahhas AF; Biochemistry Department, College of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia. anahhas@kau.edu.sa.
  • Webster TJ; Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, MA, 02115, United States.
J Nanobiotechnology ; 19(1): 305, 2021 Oct 06.
Article in English | MEDLINE | ID: covidwho-1455975
ABSTRACT
Molecular imprinting (MI) is a technique that creates a template of a molecule for improving complementary binding sites in terms of size and shape to a peptide, protein, bacteria, mammalian cell, or virus on soft materials (such as polymers, hydrogels, or self-assembled materials). MI has been widely investigated for over 90 years in various industries but is now focused on improved tissue engineering, regenerative medicine, drug delivery, sensors, diagnostics, therapeutics and other medical applications. Molecular targets that have been studied so far in MI include those for the major antigenic determinants of microorganisms (like bacteria or viruses) leading to innovations in disease diagnosis via solid-phase extraction separation and biomimetic sensors. As such, although not widely investigated yet, MI demonstrates much promise for improving the detection of and treatment for the current Coronavirus Disease of 2019 (COVID-2019) pandemic as well as future pandemics. In this manner, this review will introduce the numerous applications of MI polymers, particularly using proteins and peptides, and how these MI polymers can be used as improved diagnostic and therapeutic tools for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Molecularly Imprinted Polymers / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Limits: Humans Language: English Journal: J Nanobiotechnology Year: 2021 Document Type: Article Affiliation country: S12951-021-01032-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Molecularly Imprinted Polymers / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Limits: Humans Language: English Journal: J Nanobiotechnology Year: 2021 Document Type: Article Affiliation country: S12951-021-01032-x