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Adverse childhood experience and adult persistent pain and disability: protocol for a systematic review and meta-analysis.
Bussières, André; Hartvigsen, Jan; Ferreira, Manuela L; Ferreira, Paulo H; Hancock, Mark J; Stone, Laura S; Wideman, Timothy H; Boruff, Jill; Elklit, Ask.
  • Bussières A; School of Physical and Occupational Therapy, Faculty of Medicine, McGill University, 3630 Promenade Sir-William-Osler, Montreal, Quebec, H3G 1Y5, Canada. andre.bussieres@mcgill.ca.
  • Hartvigsen J; Département Chiropratique, Université du Québec à Trois-Rivières, 3351, boul. Des Forges, C. P. 500, Trois-Rivières, Québec, G9A 5H7, Canada. andre.bussieres@mcgill.ca.
  • Ferreira ML; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, DK-5230, Odense M, Denmark.
  • Ferreira PH; Nordic Institute of Chiropractic and Clinical Biomechanics, Campusvej 55, DK-5230, Odense M, Denmark.
  • Hancock MJ; Institute of Bone and Joint Research, The Kolling Institute, Northern Clinical School, Faculty of Medicine and Health, The University of Sydney, Level 10, Kolling Building, Royal North Shore Hospital, St Leonards, Sydney, NSW, 2065, Australia.
  • Stone LS; Musculoskeletal Health, Faculty of Health Sciences, Discipline of Physiotherapy, The University of Sydney, Room 155, O Block, Cumberland Campus C42, Sydney, NSW, 1825, Australia.
  • Wideman TH; Faculty of Medicine and Health Sciences, Macquarie University, Balaclava Road, North Ryde, Sydney, NSW, 2109, Australia.
  • Boruff J; Faculty of Dentistry, McGill University, 2001 Av McGill College #500, Montreal, Quebec, H3A1G1, Canada.
  • Elklit A; Alan Edwards Centre for Research on Pain, McGill University, 845 Sherbrooke Ouest, Montreal, Quebec, H3A 0G4, Canada.
Syst Rev ; 9(1): 215, 2020 09 17.
Article in English | MEDLINE | ID: covidwho-1456002
Semantic information from SemMedBD (by NLM)
1. Pain PROCESS_OF Adult
Subject
Pain
Predicate
PROCESS_OF
Object
Adult
2. Disability PROCESS_OF Adult
Subject
Disability
Predicate
PROCESS_OF
Object
Adult
3. Pain PROCESS_OF Adult
Subject
Pain
Predicate
PROCESS_OF
Object
Adult
4. Disability PROCESS_OF Adult
Subject
Disability
Predicate
PROCESS_OF
Object
Adult
ABSTRACT

BACKGROUND:

A growing body of research highlights the pervasive harms of adverse childhood experiences (ACEs) on health throughout the life-course. However, findings from prior reviews and recent longitudinal studies investigating the association between types of ACEs and persistent pain have yielded inconsistent findings in the strength and direction of associations. The purpose of this review is to appraise and summarize evidence on the relationship between ACEs and persistent pain and disability outcomes in adulthood. The specific aims are (1) to determine whether there is a relationship between exposure to ACE and persistent pain and disability in adults and (2) to determine whether unique and cumulative ACEs exposures (number and type) increase the risk of developing persistent pain and disability in adulthood.

METHOD:

A systematic review and meta-analysis of observational studies will be conducted. Our eligibility criteria are defined following a PECOS

approach:

population, adults with persistent (≥ 3 months) musculoskeletal and somatoform painful disorders exposed to single or cumulative direct ACEs alone (i.e., physical, sexual, emotional abuse or neglect) or in combination to indirect types of ACE (e.g., parental death, exposure to domestic violence) in the first 18 years of life; comparators, unexposed individuals; outcomes, measurements for persistent pain (≥ 3 months) and disability using discrete and/or continuous measures; and settings, general population, primary care. A comprehensive search of MEDLINE (Ovid) and nine other pertinent databases was conducted from inception to 29 August 2019 using a combination of key words and MeSh terms (the search will be updated prior to conducting the analyses). Pairs of reviewers will independently screen records and full text articles, and a third reviewer will be consulted in cases of disagreement. Data will be extracted using Endnote and Covidence and a meta-analysis will be conducted using Review Manager (RevMan) Version 5.3. The Scottish Intercollegiate Guidelines Network (SIGN) and the Joanna Briggs Institute (JBI) checklists will be used to assess the quality of the included studies. If heterogeneity is high, the findings will be presented in narrative form.

DISCUSSION:

The present review will help consolidate knowledge on persistent pain and disability by evaluating whether frequency and type of adverse childhood experiences produces the most harm. Findings may help inform practitioners and policy-makers who endeavor to prevent and/or mitigate the consequences of ACEs and promote healthy development and well-being of children, youth, and families. SYSTEMATIC REVIEW REGISTRATION PROSPERO CRD42020150230.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pain / Disabled Persons / Adverse Childhood Experiences Subject: Pain / Disabled Persons / Adverse Childhood Experiences Type of study: Observational study / Risk factors / Systematic review Language: English Journal: Syst Rev Clinical aspect: Etiology / Prognosis Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pain / Disabled Persons / Adverse Childhood Experiences Subject: Pain / Disabled Persons / Adverse Childhood Experiences Type of study: Observational study / Risk factors / Systematic review Language: English Journal: Syst Rev Clinical aspect: Etiology / Prognosis Year: 2020
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