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Interplay between the genetics of personality traits, severe psychiatric disorders and COVID-19 host genetics in the susceptibility to SARS-CoV-2 infection.
Heilbronner, Urs; Streit, Fabian; Vogl, Thomas; Senner, Fanny; Schaupp, Sabrina K; Reich-Erkelenz, Daniela; Papiol, Sergi; Oraki Kohshour, Mojtaba; Klöhn-Saghatolislam, Farahnaz; Kalman, Janos L; Heilbronner, Maria; Gade, Katrin; Comes, Ashley L; Budde, Monika; Andlauer, Till F M; Anderson-Schmidt, Heike; Adorjan, Kristina; Stürmer, Til; Loerbroks, Adrian; Amelang, Manfred; Poisel, Eric; Foo, Jerome; Heilmann-Heimbach, Stefanie; Forstner, Andreas J; Degenhardt, Franziska; Zimmermann, Jörg; Wiltfang, Jens; von Hagen, Martin; Spitzer, Carsten; Schmauss, Max; Reininghaus, Eva; Reimer, Jens; Konrad, Carsten; Juckel, Georg; Lang, Fabian U; Jäger, Markus; Figge, Christian; Fallgatter, Andreas J; Dietrich, Detlef E; Dannlowski, Udo; Baune, Bernhardt T; Arolt, Volker; Anghelescu, Ion-George; Nöthen, Markus M; Witt, Stephanie H; Andreassen, Ole A; Chen, Chi-Hua; Falkai, Peter; Rietschel, Marcella; Schulze, Thomas G.
  • Heilbronner U; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany.
  • Streit F; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
  • Vogl T; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany.
  • Senner F; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany.
  • Schaupp SK; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany.
  • Reich-Erkelenz D; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany.
  • Papiol S; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany.
  • Oraki Kohshour M; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Iran.
  • Klöhn-Saghatolislam F; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany.
  • Kalman JL; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany.
  • Heilbronner M; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany.
  • Gade K; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany.
  • Comes AL; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany.
  • Budde M; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany.
  • Andlauer TFM; Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany.
  • Anderson-Schmidt H; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany.
  • Adorjan K; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; and Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany.
  • Stürmer T; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA.
  • Loerbroks A; Institute of Occupational, Social, and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, University of Düsseldorf, Germany.
  • Amelang M; Department of Psychology, University of Heidelberg, Germany.
  • Poisel E; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
  • Foo J; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
  • Heilmann-Heimbach S; Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Germany.
  • Forstner AJ; Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Germany; and Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Germany.
  • Degenhardt F; Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Germany; and Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Germany.
  • Zimmermann J; Psychiatrieverbund Oldenburger Land gGmbH, Karl-Jaspers-Klinik, Germany.
  • Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany.
  • von Hagen M; Clinic for Psychiatry and Psychotherapy, Clinical Center Werra-Meißner, Germany.
  • Spitzer C; Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Germany.
  • Schmauss M; Department of Psychiatry, Psychotherapy and Psychosomatics, Augsburg University, Medical Faculty, Germany.
  • Reininghaus E; Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Austria.
  • Reimer J; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Germany.
  • Konrad C; Department of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Germany.
  • Juckel G; Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Germany.
  • Lang FU; Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Germany.
  • Jäger M; Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Germany.
  • Figge C; Karl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Germany.
  • Fallgatter AJ; Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University Tübingen, Germany.
  • Dietrich DE; AMEOS Clinical Center Hildesheim, Germany; and Center for Systems Neuroscience Hannover, Germany.
  • Dannlowski U; Institute for Translational Psychiatry, University of Münster, Germany.
  • Baune BT; Department of Psychiatry, University of Münster, Germany; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Australia; and The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia.
  • Arolt V; Institute for Translational Psychiatry, University of Münster, Germany.
  • Anghelescu IG; Department of Psychiatry and Psychotherapy, Mental Health Institute Berlin, Germany.
  • Nöthen MM; Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Germany.
  • Witt SH; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
  • Andreassen OA; NORMENT Centre and KG Jebsen Centre for Neurodevelopmental disorders, Institute of Clinical Medicine, University of Oslo, Norway; and Division of Mental Health and Addiction, Oslo University Hospital, Norway.
  • Chen CH; Department of Radiology, University of California, USA.
  • Falkai P; Department of Psychiatry and Psychotherapy, University Hospital, University of Munich, Munich, Germany.
  • Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
  • Schulze TG; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, University of Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, USA; and Departmen
BJPsych Open ; 7(6): e188, 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1456019
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ABSTRACT

BACKGROUND:

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, with its impact on our way of life, is affecting our experiences and mental health. Notably, individuals with mental disorders have been reported to have a higher risk of contracting SARS-CoV-2. Personality traits could represent an important determinant of preventative health behaviour and, therefore, the risk of contracting the virus.

AIMS:

We examined overlapping genetic underpinnings between major psychiatric disorders, personality traits and susceptibility to SARS-CoV-2 infection.

METHOD:

Linkage disequilibrium score regression was used to explore the genetic correlations of coronavirus disease 2019 (COVID-19) susceptibility with psychiatric disorders and personality traits based on data from the largest available respective genome-wide association studies (GWAS). In two cohorts (the PsyCourse (n = 1346) and the HeiDE (n = 3266) study), polygenic risk scores were used to analyse if a genetic association between, psychiatric disorders, personality traits and COVID-19 susceptibility exists in individual-level data.

RESULTS:

We observed no significant genetic correlations of COVID-19 susceptibility with psychiatric disorders. For personality traits, there was a significant genetic correlation for COVID-19 susceptibility with extraversion (P = 1.47 × 10-5; genetic correlation 0.284). Yet, this was not reflected in individual-level data from the PsyCourse and HeiDE studies.

CONCLUSIONS:

We identified no significant correlation between genetic risk factors for severe psychiatric disorders and genetic risk for COVID-19 susceptibility. Among the personality traits, extraversion showed evidence for a positive genetic association with COVID-19 susceptibility, in one but not in another setting. Overall, these findings highlight a complex contribution of genetic and non-genetic components in the interaction between COVID-19 susceptibility and personality traits or mental disorders.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study / Qualitative research Language: English Journal: BJPsych Open Year: 2021 Document Type: Article Affiliation country: Bjo.2021.1030

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study / Qualitative research Language: English Journal: BJPsych Open Year: 2021 Document Type: Article Affiliation country: Bjo.2021.1030