Your browser doesn't support javascript.
Quantitative serological evaluation as a valuable tool in the COVID-19 vaccination campaign.
Ferrari, Davide; Mangia, Alessandra; Spanò, Maria Sestina; Zaffarano, Lucia; Viganò, Marco; Di Resta, Chiara; Locatelli, Massimo; Ciceri, Fabio; De Vecchi, Elena.
  • Ferrari D; SCVSA Department, University of Parma, Parma, Italy.
  • Mangia A; Liver Unit, Department of Medical Sciences, IRCCS Fondazione, "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.
  • Spanò MS; Laboratory of Clinical Chemistry and Microbiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy.
  • Zaffarano L; Blood Bank Unit, Department of Medical Sciences, IRCCS Fondazione, "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.
  • Viganò M; Laboratorio di Biotecnologie Applicate all'Ortopedia, IRCCS Orthopedic Institute Galeazzi, Milan, Italy.
  • Di Resta C; IRCCS Ospedale San Raffaele, Milan, Italy.
  • Locatelli M; IRCCS Ospedale San Raffaele, Milan, Italy.
  • Ciceri F; IRCCS Ospedale San Raffaele, Milan, Italy.
  • De Vecchi E; University Vita-Salute San Raffaele, Milan, Italy.
Clin Chem Lab Med ; 59(12): 2019-2026, 2021 Nov 25.
Article in English | MEDLINE | ID: covidwho-1456116
ABSTRACT

OBJECTIVES:

After exceptional research efforts, several vaccines were developed against SARS-CoV-2 which sustains the pandemic COVID-19. The Comirnaty vaccine showed high efficacy in clinical trials and was the first to be approved for its distribution to the general population. We evaluated the immune response induced by the first vaccine dose in different sex/age groups and subjects with or without naturally present anti-SARS-CoV-2 antibodies.

METHODS:

As part of an Italian multicenter project (Covidiagnostix), serum samples from 4,290 health-professionals were serologically tested the day of the first vaccination dose, and 21 days later, using two different instrumentations (Siemens-Healthineers and Roche).

RESULTS:

In total, 97% of samples showed the presence of specific antibodies 21 days after the vaccination dose; the percentage of non-responders increased with age in both genders. Remarkably, naturally seropositive individuals showed antibody persistence up to 11 months and an exceptionally higher vaccination response compared to subjects never infected by SARS-CoV-2.

CONCLUSIONS:

This study highlighted the importance of the serological test i) to identify naturally SARS-CoV-2 seropositive individuals and ii) to evaluate the antibody level elicited by the first vaccination dose. Both tests, highlighted differences in the immune response, when subjects were stratified by sex and age, and between naturally seropositive and seronegative subjects. The data obtained show how serological tests could play a crucial role in the triage of the population subjected to the vaccination campaign for COVID-19. The definition of suitable instrumentation-specific thresholds is needed to correctly follow eventually acquired post-vaccination immunity in the general population.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunization Programs / COVID-19 Vaccines / COVID-19 / Antibodies, Viral Type of study: Randomized controlled trials Topics: Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Clin Chem Lab Med Journal subject: Chemistry, Clinical / Laboratory Techniques and procedures Year: 2021 Document Type: Article Affiliation country: Cclm-2021-0364

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunization Programs / COVID-19 Vaccines / COVID-19 / Antibodies, Viral Type of study: Randomized controlled trials Topics: Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Clin Chem Lab Med Journal subject: Chemistry, Clinical / Laboratory Techniques and procedures Year: 2021 Document Type: Article Affiliation country: Cclm-2021-0364