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Serial SARS-CoV-2 Receptor-Binding Domain Antibody Responses in Patients Receiving Dialysis.
Anand, Shuchi; Montez-Rath, Maria E; Han, Jialin; Garcia, Pablo; Cadden, LinaCel; Hunsader, Patti; Kerschmann, Russell; Beyer, Paul; Boyd, Scott D; Chertow, Glenn M; Parsonnet, Julie.
  • Anand S; Stanford University, Stanford, California (S.A., J.P.).
  • Montez-Rath ME; Stanford University, Palo Alto, California (M.E.M., P.G., S.D.B., G.M.C.).
  • Han J; Stanford University, Sunnyvale, California (J.H.).
  • Garcia P; Stanford University, Palo Alto, California (M.E.M., P.G., S.D.B., G.M.C.).
  • Cadden L; Ascend Clinical Laboratory, Redwood City, California (L.C., P.H., R.K., P.B.).
  • Hunsader P; Ascend Clinical Laboratory, Redwood City, California (L.C., P.H., R.K., P.B.).
  • Kerschmann R; Ascend Clinical Laboratory, Redwood City, California (L.C., P.H., R.K., P.B.).
  • Beyer P; Ascend Clinical Laboratory, Redwood City, California (L.C., P.H., R.K., P.B.).
  • Boyd SD; Stanford University, Palo Alto, California (M.E.M., P.G., S.D.B., G.M.C.).
  • Chertow GM; Stanford University, Palo Alto, California (M.E.M., P.G., S.D.B., G.M.C.).
  • Parsonnet J; Stanford University, Stanford, California (S.A., J.P.).
Ann Intern Med ; 174(8): 1073-1080, 2021 08.
Article in English | MEDLINE | ID: covidwho-1456490
Semantic information from SemMedBD (by NLM)
1. Antibody Formation PROCESS_OF Patients
Subject
Antibody Formation
Predicate
PROCESS_OF
Object
Patients
2. Dialysis procedure ADMINISTERED_TO Patients
Subject
Dialysis procedure
Predicate
ADMINISTERED_TO
Object
Patients
3. COVID-19 AFFECTS Persons
Subject
COVID-19
Predicate
AFFECTS
Object
Persons
4. Immune response PROCESS_OF Patients
Subject
Immune response
Predicate
PROCESS_OF
Object
Patients
5. Persistence PROCESS_OF Patients
Subject
Persistence
Predicate
PROCESS_OF
Object
Patients
6. Diabetes PROCESS_OF Human Age Group
Subject
Diabetes
Predicate
PROCESS_OF
Object
Human Age Group
7. Hypoalbuminemia PROCESS_OF Human Age Group
Subject
Hypoalbuminemia
Predicate
PROCESS_OF
Object
Human Age Group
8. Antibody Formation PROCESS_OF Patients
Subject
Antibody Formation
Predicate
PROCESS_OF
Object
Patients
9. Dialysis procedure ADMINISTERED_TO Patients
Subject
Dialysis procedure
Predicate
ADMINISTERED_TO
Object
Patients
10. COVID-19 AFFECTS Persons
Subject
COVID-19
Predicate
AFFECTS
Object
Persons
11. Immune response PROCESS_OF Patients
Subject
Immune response
Predicate
PROCESS_OF
Object
Patients
12. Persistence PROCESS_OF Patients
Subject
Persistence
Predicate
PROCESS_OF
Object
Patients
13. Diabetes PROCESS_OF Human Age Group
Subject
Diabetes
Predicate
PROCESS_OF
Object
Human Age Group
14. Hypoalbuminemia PROCESS_OF Human Age Group
Subject
Hypoalbuminemia
Predicate
PROCESS_OF
Object
Human Age Group
ABSTRACT

BACKGROUND:

Assessing the evolution of SARS-CoV-2 immune response among patients receiving dialysis can define its durability in a highly clinically relevant context because patients receiving dialysis share the characteristics of persons most susceptible to SARS-CoV-2 infection.

OBJECTIVE:

To evaluate the persistence of SARS-CoV-2 receptor-binding domain (RBD) IgG in seroprevalent patients receiving dialysis.

DESIGN:

Prospective.

SETTING:

Nationwide sample from dialysis facilities. PATIENTS 2215 patients receiving dialysis who had evidence of SARS-CoV-2 infection as of July 2020. MEASUREMENTS Remainder plasma from routine monthly laboratories was used to measure semiquantitative RBD IgG index value over 6 months.

RESULTS:

A total of 2063 (93%) seroprevalent patients reached an assay detectable response (IgG index value ≥1). Most (n = 1323, 60%) had responses in July with index values classified as high (IgG ≥10); 1003 (76%) remained within this stratum. Adjusted median index values declined slowly but continuously (July vs. December values were 21 vs. 13; P < 0.001). The trajectory of the response did not vary by age group, sex, race/ethnicity, or diabetes status. Patients without an assay detectable response (n = 137) were more likely to be White and in the younger (18 to 44 years) or older (≥80 years) age groups and less likely to have diabetes and hypoalbuminemia.

LIMITATION:

Lack of data on symptoms or reverse transcriptase polymerase chain reaction diagnosis, cohort of persons who survived infection, and use of a semiquantitative assay.

CONCLUSION:

Despite impaired immunity, most seropositive patients receiving dialysis maintained RBD antibody levels over 6 months. A slow and continual decline in median antibody levels over time was seen, but no indication that subgroups with impaired immunity had a shorter-lived humoral response was found. PRIMARY FUNDING SOURCE Ascend Clinical Laboratories.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Immunoglobulin G / Renal Dialysis / Spike Glycoprotein, Coronavirus / Protein Domains / COVID-19 / Antibodies, Viral Subject: Immunoglobulin G / Renal Dialysis / Spike Glycoprotein, Coronavirus / Protein Domains / COVID-19 / Antibodies, Viral Type of study: Observational study / Prognostic study Language: English Journal: Ann Intern Med Clinical aspect: Etiology / Prognosis Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Immunoglobulin G / Renal Dialysis / Spike Glycoprotein, Coronavirus / Protein Domains / COVID-19 / Antibodies, Viral Subject: Immunoglobulin G / Renal Dialysis / Spike Glycoprotein, Coronavirus / Protein Domains / COVID-19 / Antibodies, Viral Type of study: Observational study / Prognostic study Language: English Journal: Ann Intern Med Clinical aspect: Etiology / Prognosis Year: 2021
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