Trained Immunity: Reprogramming Innate Immunity in Health and Disease.
Annu Rev Immunol
; 39: 667-693, 2021 04 26.
Article
in English
| MEDLINE | ID: covidwho-1457607
ABSTRACT
Traditionally, the innate and adaptive immune systems are differentiated by their specificity and memory capacity. In recent years, however, this paradigm has shifted Cells of the innate immune system appear to be able to gain memory characteristics after transient stimulation, resulting in an enhanced response upon secondary challenge. This phenomenon has been called trained immunity. Trained immunity is characterized by nonspecific increased responsiveness, mediated via extensive metabolic and epigenetic reprogramming. Trained immunity explains the heterologous effects of vaccines, which result in increased protection against secondary infections. However, in chronic inflammatory conditions, trained immunity can induce maladaptive effects and contribute to hyperinflammation and progression of cardiovascular disease, autoinflammatory syndromes, and neuroinflammation. In this review we summarize the current state of the field of trained immunity, its mechanisms, and its roles in both health and disease.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vaccines
/
Immunologic Memory
Topics:
Vaccines
Limits:
Animals
/
Humans
Language:
English
Journal:
Annu Rev Immunol
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS