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A Retrospective Cohort Study of Young Women Spontaneously Choosing to Be Vaccinated against HPV: Outcomes from Their First Cervical Cancer Screening Test.
Del Mistro, Annarosa; Battagello, Jessica; Weis, Luca; Bressan, Vittoria; Selle, Vittorio; Ramigni, Mauro; Dal Zotto, Alessandra; Maggiolo, Antonio; Gori, Silvia; Frayle, Helena; Zappa, Marco; Zorzi, Manuel.
  • Del Mistro A; Immunologia e Diagnostica Molecolare Oncologica, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata, 64, 35128 Padua, Italy.
  • Battagello J; Veneto Tumour Registry, Azienda Zero, 35131 Padua, Italy.
  • Weis L; Immunologia e Diagnostica Molecolare Oncologica, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata, 64, 35128 Padua, Italy.
  • Bressan V; Department of Neuroscience (DNS), University of Padua, 35131 Padua, Italy.
  • Selle V; Local Health Unit Euganea, 35131 Padua, Italy.
  • Ramigni M; Local Health Unit Serenissima, 30174 Venezia, Italy.
  • Dal Zotto A; Local Health Unit Marca Trevigiana, 31100 Treviso, Italy.
  • Maggiolo A; Local Health Unit Pedemontana, 36061 Bassano del Grappa, Italy.
  • Gori S; Local Health Unit Scaligera, 37121 Verona, Italy.
  • Frayle H; Immunologia e Diagnostica Molecolare Oncologica, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata, 64, 35128 Padua, Italy.
  • Zappa M; Immunologia e Diagnostica Molecolare Oncologica, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata, 64, 35128 Padua, Italy.
  • Zorzi M; Institute for Cancer Research, Prevention and Clinical Network (ISPRO), 50139 Florence, Italy.
  • The Consensus Study Veneto Working Group; Veneto Tumour Registry, Azienda Zero, 35131 Padua, Italy.
Viruses ; 13(3)2021 03 16.
Article in English | MEDLINE | ID: covidwho-1457709
Semantic information from SemMedBD (by NLM)
1. Post-pubertal PROCESS_OF Woman
Subject
Post-pubertal
Predicate
PROCESS_OF
Object
Woman
2. Malignant tumor of cervix PROCESS_OF Woman
Subject
Malignant tumor of cervix
Predicate
PROCESS_OF
Object
Woman
3. High Grade Lesion PROCESS_OF Woman
Subject
High Grade Lesion
Predicate
PROCESS_OF
Object
Woman
4. Compliance PROCESS_OF Woman
Subject
Compliance
Predicate
PROCESS_OF
Object
Woman
5. Post-pubertal PROCESS_OF Woman
Subject
Post-pubertal
Predicate
PROCESS_OF
Object
Woman
6. Malignant tumor of cervix PROCESS_OF Woman
Subject
Malignant tumor of cervix
Predicate
PROCESS_OF
Object
Woman
7. High Grade Lesion PROCESS_OF Woman
Subject
High Grade Lesion
Predicate
PROCESS_OF
Object
Woman
8. Compliance PROCESS_OF Woman
Subject
Compliance
Predicate
PROCESS_OF
Object
Woman
ABSTRACT

BACKGROUND:

Efficacy for cervical cancer prevention of opportunistic HPV vaccination in post-pubertal girls is lower than in 11-year-olds.

METHODS:

Women born between 1986 and 1992 vaccinated at 15-25 years of age (at least one dose of 4-valent HPV vaccine) and screened at 24-27 years of age were included. Frequency of opportunistic vaccination, overall and by birth cohort, was calculated; screening outcomes were compared between vaccinated and unvaccinated women.

RESULTS:

Overall, 4718 (4.9%) HPV-vaccinated, and 91,512 unvaccinated, women were studied. The frequency of vaccination increased by birth cohort, ranging between 1.8% and 9.8%; age at vaccination decreased progressively by birth cohort (p < 0.0001). Participation in screening was 60.8% among vaccinated, and 56.6% among unvaccinated, women (p < 0.0001). Detection rates (DR) for high-grade lesions were lower in vaccinated women (2.11‰ vs. 3.85‰ in unvaccinated, for CIN3+, p = 0.24; 0.0‰ vs. 0.22‰ for cancer). The DR of CIN3+ increased with age at vaccination, scoring respectively 0.0‰, 0.83‰, and 4.68‰ for women vaccinated when they were 15-16, 17-20, and 21-25 years old (p = 0.17).

CONCLUSIONS:

In comparison to unvaccinated women, higher compliance with cervical cancer screening invitation and lower CIN3+ DR among vaccinated women was observed. Age at vaccination was inversely correlated to vaccination efficacy.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Uterine Cervical Neoplasms / Papillomavirus Infections / Papillomavirus Vaccines Subject: Uterine Cervical Neoplasms / Papillomavirus Infections / Papillomavirus Vaccines Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors / Screening study Language: English Clinical aspect: Etiology Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Uterine Cervical Neoplasms / Papillomavirus Infections / Papillomavirus Vaccines Subject: Uterine Cervical Neoplasms / Papillomavirus Infections / Papillomavirus Vaccines Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors / Screening study Language: English Clinical aspect: Etiology Year: 2021
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