Brain Organoids: Studying Human Brain Development and Diseases in a Dish.
Stem Cells Int
; 2021: 5902824, 2021.
Article
in English
| MEDLINE | ID: covidwho-1458469
ABSTRACT
With the rapid development of stem cell technology, the advent of three-dimensional (3D) cultured brain organoids has opened a new avenue for studying human neurodevelopment and neurological disorders. Brain organoids are stem-cell-derived 3D suspension cultures that self-assemble into an organized structure with cell types and cytoarchitectures recapitulating the developing brain. In recent years, brain organoids have been utilized in various aspects, ranging from basic biology studies, to disease modeling, and high-throughput screening of pharmaceutical compounds. In this review, we overview the establishment and development of brain organoid technology, its recent progress, and translational applications, as well as existing limitations and future directions.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
Stem Cells Int
Year:
2021
Document Type:
Article
Affiliation country:
2021
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