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A new standard scoring for interstitial pneumonia based on quantitative analysis of ultrasonographic data: A study on COVID-19 patients.
Lombardi, Fiorella Anna; Franchini, Roberto; Morello, Rocco; Casciaro, Ernesto; Ianniello, Stefania; Serra, Maurizio; Satriano, Francesco; Mojoli, Francesco; Mongodi, Silvia; Pignatelli, Daniela; Di Paola, Marco; Casciaro, Sergio.
  • Lombardi FA; National Research Council - Institute of Clinical Physiology, Lecce, Italy. Electronic address: fiorella@ifc.cnr.it.
  • Franchini R; National Research Council - Institute of Clinical Physiology, Lecce, Italy.
  • Morello R; National Research Council - Institute of Clinical Physiology, Lecce, Italy.
  • Casciaro E; National Research Council - Institute of Clinical Physiology, Lecce, Italy.
  • Ianniello S; Diagnostic Imaging Unit, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, Rome, Italy.
  • Serra M; Pneumology Unit 2, Vito Fazzi Hospital, ASL Lecce, Lecce, Italy.
  • Satriano F; Pneumology Unit 2, Vito Fazzi Hospital, ASL Lecce, Lecce, Italy.
  • Mojoli F; Department of clinical-surgical, diagnostic and pediatric sciences, Unit of anesthesia and intensive care, University of Pavia, Pavia, Italy; Anesthesia and Intensive Care, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.
  • Mongodi S; Anesthesia and Intensive Care, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.
  • Pignatelli D; National Research Council - Institute of Clinical Physiology, Lecce, Italy.
  • Di Paola M; National Research Council - Institute of Clinical Physiology, Lecce, Italy.
  • Casciaro S; National Research Council - Institute of Clinical Physiology, Lecce, Italy.
Respir Med ; 189: 106644, 2021.
Article in English | MEDLINE | ID: covidwho-1458699
ABSTRACT

OBJECTIVE:

To assess the effectiveness of 3 novel lung ultrasound (LUS)-based parameters Pneumonia Score and Lung Staging for pneumonia staging and COVID Index, indicating the probability of SARS-CoV-2 infection.

METHODS:

Adult patients admitted to the emergency department with symptoms potentially related to pneumonia, healthy volunteers and clinical cases from online accessible databases were evaluated. The patients underwent a clinical-epidemiological questionnaire and a LUS acquisition, following a 14-zone protocol. For each zone, a Pneumonia score from 0 to 4 was assigned by the algorithm and by an expert operator (kept blind with respect to the algorithm results) on the basis of the identified imaging signs and the patient Lung Staging was derived as the highest observed score. The output of the operator was considered as the ground truth. The algorithm calculated also the COVID Index by combining the automatically identified LUS markers with the questionnaire answers and compared with the nasopharyngeal swab results.

RESULTS:

Overall, 556 patients were analysed. A high agreement between the algorithm assignments and the expert operator evaluations was observed, both for Pneumonia Score and Lung Staging, with the latter having sensitivity and specificity over 92% both in the discrimination between healthy/sick patients and between sick patients with mild/severe pneumonia. Regarding the COVID Index, an area under the curve of 0.826 was observed for the classification of patients with/without SARS-CoV-2.

CONCLUSION:

The proposed methodology allowed the identification and staging of patients suffering from pneumonia with high accuracy. Moreover, it provided the probability of being infected by SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Research Design / Ultrasonography / Lung Diseases, Interstitial / COVID-19 / Lung Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Respir Med Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Research Design / Ultrasonography / Lung Diseases, Interstitial / COVID-19 / Lung Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Respir Med Year: 2021 Document Type: Article