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Neurological symptoms of COVID-19 infection; a cross-sectional study on hospitalized COVID-19 patients in Iran.
Nejad, Javad Hosseini; Allahyari, Fakhri; Hosseinzadeh, Ramin; Heiat, Mohammad; Ranjbar, Reza.
  • Nejad JH; Neuroscience research center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Allahyari F; Neuroscience research center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Hosseinzadeh R; Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Heiat M; Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Ranjbar R; Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran. Electronic address: ranjbarre@gmail.com.
Clin Neurol Neurosurg ; 210: 106985, 2021 11.
Article in English | MEDLINE | ID: covidwho-1458745
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19), a global issue now, can have a variety of clinical manifestations. Hundreds of articles have discussed different aspects of this infectious disease, such as physiopathology, epidemiology, clinical manifestations and treatment protocols. Recently, neurological manifestations of the disease have been found to be pretty common among COVID-19 patients. Here, neurological symptoms of COVID-19 infection with a focus on non-cerebrovascular complications are discussed in a large study population.

METHODS:

Neurological symptoms of 891hospitalized COVID-19 patients from March to June 2020 in a major Hospital, Tehran, Iran, were reviewed. Demographic characteristics and neurological manifestations were analyzed.

RESULTS:

Among 891 hospitalized COVID-19 patients, the following symptoms were observed headache (63.9%), sleeping problems (51.3%), hyposmia/anosmia (46%), dizziness (45.4%), hypogeusia (42.1%), memory issues (31.5%), auditory disturbances (17.5%), paralysis (3.7%) and seizures (1.7%). In 29.7% of the patients, a neurological symptom was the initiating symptoms of the infection. Females were more likely to show headache and dizziness compared to males (p value<0.05). Headache intensity was also higher in females compared to males (p value<0.05). Headache prevalence was lower in older patients (p value<0.05), while memory loss and impaired consciousness were higher by increasing age (p values=0.002 and 0.001, respectively).

CONCLUSION:

Neurological manifestations were common among COVID-19 patients under study. Headache, as the most common neurological symptom among COVID-19 patients, was the most prevalent and intense among the female population. Headache, dizziness, sleeping problems, hyposmia/anosmia and hypogeusia were common COVID-19 neurological manifestations, while memory issues, auditory disturbances, paralysis, and seizures were less common.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hospitalization / Nervous System Diseases Type of study: Diagnostic study / Clinical Practice Guide / Observational study / Prevalence study / Randomized controlled trials / Risk factors Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Clin Neurol Neurosurg Year: 2021 Document Type: Article Affiliation country: J.clineuro.2021.106985

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hospitalization / Nervous System Diseases Type of study: Diagnostic study / Clinical Practice Guide / Observational study / Prevalence study / Randomized controlled trials / Risk factors Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Clin Neurol Neurosurg Year: 2021 Document Type: Article Affiliation country: J.clineuro.2021.106985