Peripheral Artery Disease and COVID-19 Outcomes: Insights from the Yale DOM-CovX Registry.
Curr Probl Cardiol
; 47(12): 101007, 2022 Dec.
Article
in English
| MEDLINE | ID: covidwho-1458816
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT
Both COVID-19 infection and peripheral arterial disease (PAD) cause hypercoagulability in patients, and it remains unknown whether PAD predisposes patients to experience worse outcomes when infected with SARS-CoV-2. The Yale DOM-CovX Registry consecutively enrolled inpatients for SARS-CoV-2 between March 1, 2020, and November 10, 2020. Adjusted logistic regression models examined associations between PAD and mortality, stroke, myocardial infarction (MI), and major adverse cardiovascular events (MACE, all endpoints combined). Of the 3830 patients were admitted with SARS-CoV-2, 50.5% were female, mean age was 63.1 ± 18.4 years, 50.7% were minority race, and 18.3% (nâ¯=â¯693) had PAD. PAD was independently associated with increased mortality (ORâ¯=â¯1.45, 95% CI 1.11-1.88) and MACE (ORâ¯=â¯1.48, 95% CI 1.16-1.87). PAD was not independently associated with stroke (P = 0.06) and MI (P = 0.22). Patients with PAD have a >40% odds of mortality and MACE when admitted with a SARS-CoV-2, independent of known risk factors.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Stroke
/
Peripheral Arterial Disease
/
COVID-19
/
Myocardial Infarction
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Curr Probl Cardiol
Year:
2022
Document Type:
Article
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