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Differential roles of interferons in innate responses to mucosal viral infections.
Walker, Forrest C; Sridhar, Pratyush R; Baldridge, Megan T.
  • Walker FC; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
  • Sridhar PR; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
  • Baldridge MT; Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: mbaldridge@wustl.edu.
Trends Immunol ; 42(11): 1009-1023, 2021 11.
Article in English | MEDLINE | ID: covidwho-1458853
ABSTRACT
Interferons (IFNs) are among the first vertebrate immune pathways activated upon viral infection and are crucial for control of viral replication and dissemination, especially at mucosal surfaces as key locations for host exposure to pathogens. Inhibition of viral establishment and spread at and from these mucosal sites is paramount for preventing severe disease, while concomitantly limiting putative detrimental effects of inflammation. Here, we compare the roles of type I, II, and III IFNs in regulating three archetypal viruses - norovirus, herpes simplex virus, and severe acute respiratory virus coronavirus 2 (SARS-CoV-2) - which infect distinct mammalian mucosal tissues. Emerging paradigms include highly specific roles for IFNs in limiting local versus systemic infection, synergistic activities, and a spectrum of protective versus detrimental effects of IFNs during the infection response.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / COVID-19 Limits: Animals / Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.it.2021.09.003

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / COVID-19 Limits: Animals / Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: J.it.2021.09.003