Association of HLA class I and II genes with Middle East respiratory syndrome coronavirus infection in Koreans.
Immun Inflamm Dis
; 10(1): 111-116, 2022 01.
Article
in English
| MEDLINE | ID: covidwho-1459944
ABSTRACT
INTRODUCTION:
Middle East Respiratory Syndrome (MERS) caused by MERS-coronavirus (CoV) is a lower respiratory tract disease characterized by a high mortality rate. MERS-CoV spread from Saudi Arabia to other countries, including South Korea. Dysfunction of the human leukocyte antigen (HLA) system has many effects due to genetic complexity and its role in the adaptive immune response. We investigated the association of HLA class I and II alleles with MERS-CoV in 32 patients with MERS.METHODS:
HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 were genotyped by polymerase chain reaction sequence-based typing.RESULTS:
HLA-DQB1*0302 are significantly associated with moderate/mild cases of MERS-CoV. Other alleles are no statistical significance.CONCLUSIONS:
Treatment strategies based on current research on the HLA gene and MERS-CoV will provide potential therapeutic targets.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Genes, MHC Class I
/
Genes, MHC Class II
/
Middle East Respiratory Syndrome Coronavirus
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Immun Inflamm Dis
Year:
2022
Document Type:
Article
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