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Genomic Characterization of a Novel Alphacoronavirus Isolated from Bats, Korea, 2020.
Do, Hai-Quynh; Nguyen, Van-Giap; Chung, Chul-Un; Jeon, Yong-Shin; Shin, Sook; Jang, Kuem-Chan; Pham, Le Bich Hang; Kong, Aeri; Kim, Cheong-Ung; Park, Yong-Ho; Park, Bong-Kyun; Chung, Hee-Chun.
  • Do HQ; Virology Lab, Department of Veterinary Medicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.
  • Nguyen VG; Department of Veterinary Microbiology and Infectious Diseases, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi 100000, Vietnam.
  • Chung CU; Department of Life Science, Dongguk University, Gyeongju 38066, Korea.
  • Jeon YS; Department of Life Science, Dongguk University, Gyeongju 38066, Korea.
  • Shin S; Noah Biotech Research Unit, Noah Biotech Co., Ltd., Suwon 16612, Korea.
  • Jang KC; Noah Biotech Research Unit, Noah Biotech Co., Ltd., Suwon 16612, Korea.
  • Pham LBH; Institute of Genome Research, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam.
  • Kong A; Department of Medical Science, University of California, Los Angeles, CA 90095, USA.
  • Kim CU; Department of Veterinary Medicine Microbology Lab, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.
  • Park YH; Noah Biotech Research Unit, Noah Biotech Co., Ltd., Suwon 16612, Korea.
  • Park BK; Virology Lab, Department of Veterinary Medicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.
  • Chung HC; Virology Lab, Department of Veterinary Medicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Korea.
Viruses ; 13(10)2021 10 11.
Article in English | MEDLINE | ID: covidwho-1460086
ABSTRACT
Coronavirus, an important zoonotic disease, raises concerns of future pandemics. The bat is considered a source of noticeable viruses resulting in human and livestock infections, especially the coronavirus. Therefore, surveillance and genetic analysis of coronaviruses in bats are essential in order to prevent the risk of future diseases. In this study, the genome of HCQD-2020, a novel alphacoronavirus detected in a bat (Eptesicus serotinus), was assembled and described using next-generation sequencing and bioinformatics analysis. The comparison of the whole-genome sequence and the conserved amino acid sequence of replicated proteins revealed that the new strain was distantly related with other known species in the Alphacoronavirus genus. Phylogenetic construction indicated that this strain formed a separated branch with other species, suggesting a new species of Alphacoronavirus. Additionally, in silico prediction also revealed the risk of cross-species infection of this strain, especially in the order Artiodactyla. In summary, this study provided the genetic characteristics of a possible new species belonging to Alphacoronavirus.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chiroptera / Genome, Viral / Coronavirus Infections / Alphacoronavirus Type of study: Prognostic study / Randomized controlled trials Limits: Animals Country/Region as subject: Asia Language: English Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chiroptera / Genome, Viral / Coronavirus Infections / Alphacoronavirus Type of study: Prognostic study / Randomized controlled trials Limits: Animals Country/Region as subject: Asia Language: English Year: 2021 Document Type: Article