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The impact of COVID-19 lockdown on brain metabolism.
Guedj, Eric; Campion, Jacques-Yves; Horowitz, Tatiana; Barthelemy, Fanny; Cammilleri, Serge; Ceccaldi, Mathieu.
  • Guedj E; Nuclear Medicine Department, Aix-Marseille University, APHM, CNRS, Centrale Marseille, Institut Fresnel, Timone Hospital, CERIMED, Marseille, France.
  • Campion JY; Nuclear Medicine Department, Aix-Marseille University, APHM, CNRS, Centrale Marseille, Institut Fresnel, Timone Hospital, CERIMED, Marseille, France.
  • Horowitz T; Nuclear Medicine Department, Aix-Marseille University, APHM, CNRS, Centrale Marseille, Institut Fresnel, Timone Hospital, CERIMED, Marseille, France.
  • Barthelemy F; Nuclear Medicine Department, Aix-Marseille University, APHM, CNRS, Centrale Marseille, Institut Fresnel, Timone Hospital, CERIMED, Marseille, France.
  • Cammilleri S; Nuclear Medicine Department, Aix-Marseille University, APHM, CNRS, Centrale Marseille, Institut Fresnel, Timone Hospital, CERIMED, Marseille, France.
  • Ceccaldi M; Service de Neurologie et de Neuropsychologie, Aix Marseille University, INSERM, Inst Neurosci Syst, & APHM, CHU Timone, Marseille, France.
Hum Brain Mapp ; 43(2): 593-597, 2022 02 01.
Article in English | MEDLINE | ID: covidwho-1460200
ABSTRACT
This study aims to evaluate the impact of French national lockdown of 55 days on brain metabolism of patients with neurological disorders. Whole-brain voxel-based PET analysis was used to correlate 18 F-FDG metabolism to the number of days after March 17, 2020 (in 95 patients; mean age 54.3 years ± 15.7; 59 men), in comparison to the same period in 2019 before the SARS-CoV-2 outbreak (in 212 patients; mean age 59.5 years ± 15.8; 114 men), and to the first 55 days of deconfinement (in 188 patients; mean age 57.5 years ± 16.5; 93 men). Lockdown duration was negatively correlated to the metabolism of the sensory-motor cortex with a prevailing effect on the left dominant pyramidal tract and on younger patients, also including the left amygdala, with only partial reversibility after 55 days of deconfinement. Weak overlap was found with the reported pattern of hypometabolism in long COVID (<9%). Restriction of physical activities, and possible related deconditioning, and social isolation may lead to functional disturbances of sensorimotor and emotional brain networks. Of note, this metabolic pattern seems distinct to those reported in long COVID. Further longitudinal studies with longer follow-up are needed to evaluate clinical consequences and relationships on cognitive and mental health against functional deactivation hypothesis, and to extend these findings to healthy subjects in the context of lockdown.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Quarantine / Pandemics / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Hum Brain Mapp Journal subject: Brain Year: 2022 Document Type: Article Affiliation country: Hbm.25673

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain / Quarantine / Pandemics / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Hum Brain Mapp Journal subject: Brain Year: 2022 Document Type: Article Affiliation country: Hbm.25673