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Clinical and immunological characteristics in COVID-19 convalescent patients.
Su, Zhiying; Hu, Wenjia; Liu, Qianyun; Zhang, Yongxi; Chen, Tielong; Zhou, Yingying; Zhang, Zhen; Chen, Yu; Yang, Rongrong; Xiong, Yong; Wang, Xinghuan.
  • Su Z; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
  • Hu W; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
  • Liu Q; State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.
  • Zhang Y; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
  • Chen T; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
  • Zhou Y; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
  • Zhang Z; State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.
  • Chen Y; State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.
  • Yang R; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
  • Xiong Y; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China. yongxiong64@163.com.
  • Wang X; Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
Eur J Clin Microbiol Infect Dis ; 40(12): 2669-2676, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1460345
ABSTRACT
The humoral and cellular immunity of convalescent COVID-19 patients is involved in pathogenesis and vaccine immunity. In this study, through CoV-psV neutralization assay and IFN-γ ELISpot testing in 30 cases of COVID-19 patients after 9 months post-SARS-CoV-2 infection, it found that the ratio of memory/naive CD4+ T lymphocytes cells and levels of anti-SARS-CoV-2-IgM and RBD-IgM were slightly but significantly higher in COVID-19 severe convalescent patients than that in non-severe patients. The specific cellular and humoral immunity against SARS-CoV-2 were detectable, regardless of the severity of the disease in the acute phase. This information may help understanding the immune status after SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Eur J Clin Microbiol Infect Dis Journal subject: Communicable Diseases / Microbiology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Eur J Clin Microbiol Infect Dis Journal subject: Communicable Diseases / Microbiology Year: 2021 Document Type: Article