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The Repurposed ACE2 Inhibitors: SARS-CoV-2 Entry Blockers of Covid-19.
Ahmad, Iqrar; Pawara, Rahul; Surana, Sanjay; Patel, Harun.
  • Ahmad I; Division of Computer Aided Drug Design, Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur (Dhule), Maharashtra, 425405, India.
  • Pawara R; Division of Computer Aided Drug Design, Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur (Dhule), Maharashtra, 425405, India.
  • Surana S; Division of Computer Aided Drug Design, Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur (Dhule), Maharashtra, 425405, India.
  • Patel H; Division of Computer Aided Drug Design, Department of Pharmaceutical Chemistry, R.C. Patel Institute of Pharmaceutical Education and Research, Shirpur (Dhule), Maharashtra, 425405, India. hpatel_38@yahoo.com.
Top Curr Chem (Cham) ; 379(6): 40, 2021 Oct 08.
Article in English | MEDLINE | ID: covidwho-1460532
ABSTRACT
The highly infectious disease COVID-19 is induced by SARS-coronavirus 2 (SARS-CoV-2), which has spread rapidly around the globe and was announced as a pandemic by the World Health Organization (WHO) in March 2020. SARS-CoV-2 binds to the host cell's angiotensin converting enzyme 2 (ACE2) receptor through the viral surface spike glycoprotein (S-protein). ACE2 is expressed in the oral mucosa and can therefore constitute an essential route for entry of SARS-CoV-2 into hosts through the tongue and lung epithelial cells. At present, no effective treatments for SARS-CoV-2 are yet in place. Blocking entry of the virus by inhibiting ACE2 is more advantageous than inhibiting the subsequent stages of the SARS-CoV-2 life cycle. Based on current published evidence, we have summarized the different in silico based studies and repurposing of anti-viral drugs to target ACE2, SARS-CoV-2 S-Protein ACE2 and SARS-CoV-2 S-RBD ACE2. This review will be useful to researchers looking to effectively recognize and deal with SARS-CoV-2, and in the development of repurposed ACE2 inhibitors against COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Protease Inhibitors / Virus Internalization / Drug Repositioning / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 Limits: Animals / Humans Language: English Journal: Top Curr Chem (Cham) Year: 2021 Document Type: Article Affiliation country: S41061-021-00353-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Protease Inhibitors / Virus Internalization / Drug Repositioning / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 Limits: Animals / Humans Language: English Journal: Top Curr Chem (Cham) Year: 2021 Document Type: Article Affiliation country: S41061-021-00353-7