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sFlt-1 and CA 15.3 are indicators of endothelial damage and pulmonary fibrosis in SARS-CoV-2 infection.
Greco, Marilena; Suppressa, Salvatore; Lazzari, Roberta Assunta; Sicuro, Fernando; Catanese, Carmelo; Lobreglio, Giambattista.
  • Greco M; Clinical Pathology and Microbiology, Vito Fazzi General Hospital ASL-Lecce, 73100 Piazza Muratore, Lecce, Italy. grecomarilena@gmail.com.
  • Suppressa S; Clinical Pathology and Microbiology, Vito Fazzi General Hospital ASL-Lecce, 73100 Piazza Muratore, Lecce, Italy.
  • Lazzari RA; Clinical Pathology and Microbiology, Vito Fazzi General Hospital ASL-Lecce, 73100 Piazza Muratore, Lecce, Italy.
  • Sicuro F; Clinical Pathology and Microbiology, Vito Fazzi General Hospital ASL-Lecce, 73100 Piazza Muratore, Lecce, Italy.
  • Catanese C; Intensive Care Unit, Vito Fazzi General Hospital ASL-Lecce, Lecce, Italy.
  • Lobreglio G; Clinical Pathology and Microbiology, Vito Fazzi General Hospital ASL-Lecce, 73100 Piazza Muratore, Lecce, Italy.
Sci Rep ; 11(1): 19979, 2021 10 07.
Article in English | MEDLINE | ID: covidwho-1462032
ABSTRACT
COVID-19 pandemic led to a worldwide increase of hospitalizations for interstitial pneumonia with thrombosis complications, endothelial injury and multiorgan disease. Common CT findings include lung bilateral infiltrates, bilateral ground-glass opacities and/or consolidation whilst no current laboratory parameter consents rapidly evaluation of COVID-19 risk and disease severity. In the present work we investigated the association of sFLT-1 and CA 15.3 with endothelial damage and pulmonary fibrosis. Serum sFlt-1 has been associated with endothelial injury and sepsis severity, CA 15.3 seems an alternative marker for KL-6 for fibrotic lung diseases and pulmonary interstitial damage. We analysed 262 SARS-CoV-2 patients with differing levels of clinical severity; we found an association of serum sFlt-1 (ROC AUC 0.902, decision threshold > 90.3 pg/mL, p < 0.001 Sens. 83.9% and Spec. 86.7%) with presence, extent and severity of the disease. Moreover, CA 15.3 appeared significantly increased in COVID-19 severe lung fibrosis (ICU vs NON-ICU patients 42.6 ± 3.3 vs 25.7 ± 1.5 U/mL, p < 0.0001) and was associated with lung damage severity grade (ROC AUC 0.958, decision threshold > 24.8 U/mL, p < 0.0001, Sens. 88.4% and Spec. 91.8%). In conclusion, serum levels of sFlt-1 and CA 15.3 appeared useful tools for categorizing COVID-19 clinical stage and may represent a valid aid for clinicians to better personalise treatment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Fibrosis / Mucin-1 / Vascular Endothelial Growth Factor Receptor-1 / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-99470-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Fibrosis / Mucin-1 / Vascular Endothelial Growth Factor Receptor-1 / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-99470-y