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Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) RNA in the Human Eye.
Kamalipour, Alireza; Ashraf, Mohammad Ali; Moghimi, Sasan; Moattari, Afagh; Ashraf, Mohammad Javad; Abbasi, Farhad; Azodi, Farzan; Oboudi, Shadi; Pirbonyeh, Neda; Mokhtaryan, Maryam; Roshanshad, Amirhossein; Do, Jiun L; Weinreb, Robert N.
  • Kamalipour A; Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, California, USA.
  • Ashraf MA; Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Moghimi S; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Moattari A; Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, California, USA.
  • Ashraf MJ; Department of Virology and Bacteriology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Abbasi F; Bioinformatics and Computational Biology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Azodi F; Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Oboudi S; Department of Infectious Diseases, Bushehr University of Medical Sciences, Bushehr, Iran.
  • Pirbonyeh N; Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran.
  • Mokhtaryan M; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Roshanshad A; Department of Virology and Bacteriology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Do JL; Department of Microbiology, Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Weinreb RN; Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Ocul Immunol Inflamm ; : 1-7, 2021 Oct 12.
Article in English | MEDLINE | ID: covidwho-2241968
ABSTRACT

PURPOSE:

To determine the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in postmortem ocular specimens of patients with severe COVID-19 disease. PATIENTS AND

METHODS:

Postmortem conjunctival (28 samples), aqueous humor (30 samples) and vitreous humor (30 samples) specimens were obtained bilaterally from the eyes of 15 deceased COVID-19 patients within one hour of death. The presence of viral RNA was evaluated in samples using Real-time reverse transcriptase-polymerase chain reaction (RT-PCR).

RESULTS:

Positive RT-PCR SARS-COV-2 results were found in one conjunctival and 2 vitreous humor samples. All aqueous humor samples tested negative for the presence of SARS-COV-2 RNA. Of note, three positive samples were obtained from three different patients. The overall prevalence of positive RT-PCR ocular samples was 3.4% among all samples and 20% at the patient level.

CONCLUSION:

SARS-CoV-2 RNA is detectable in postmortem conjunctival and vitreous humor samples of patients with severe COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study Language: English Journal: Ocul Immunol Inflamm Journal subject: Allergy and Immunology / Ophthalmology Year: 2021 Document Type: Article Affiliation country: 09273948.2021.1980810

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study Language: English Journal: Ocul Immunol Inflamm Journal subject: Allergy and Immunology / Ophthalmology Year: 2021 Document Type: Article Affiliation country: 09273948.2021.1980810