Herpes Simplex Virus Keratitis Reactivation after SARS-CoV-2 BNT162b2 mRNA Vaccination: A Report of Two Cases.
Ocul Immunol Inflamm
; 29(6): 1238-1240, 2021 Aug 18.
Article
in English
| MEDLINE | ID: covidwho-1462164
ABSTRACT
PURPOSE:
To report two cases of herpes simplex virus keratitis reactivation following Pfizer-BioNTech COVID-19 (BNT162b2) mRNA vaccination.METHODS:
Two patients (one male, age 42 years, and one female, age 29 years) who are known to have herpetic keratitis presented to our emergency room in a time frame between 4 days and 4 weeks of receiving the vaccine. One patient presented with necrotizing stromal keratitis; the other presented with endotheliitis and epithelial keratitis. PCR for herpes simplex virus (HSV) was obtained from the two patients, and all cases received systemic acyclovir.RESULTS:
PCR for HSV came positive in both cases. Patients responded well to the provided treatment.CONCLUSION:
Ocular herpetic infection may be activated by COVID-19 (BNT162b2) mRNA vaccine. Treating physician should be alert to such associations, and patients should be followed closely. No direct causality has been proven, but further reporting and investigating similar conditions is recommended.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vaccination
/
Keratitis, Herpetic
/
Latent Infection
/
SARS-CoV-2
/
COVID-19
/
BNT162 Vaccine
Type of study:
Case report
/
Diagnostic study
/
Observational study
Topics:
Vaccines
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Ocul Immunol Inflamm
Journal subject:
Allergy and Immunology
/
Ophthalmology
Year:
2021
Document Type:
Article
Affiliation country:
09273948.2021.1986548
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