Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2.
Sci Immunol
; 6(64): eabl4509, 2021 Oct 15.
Article
in English
| MEDLINE | ID: covidwho-1462897
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 160 million infections and more than 3 million deaths worldwide. Although effective vaccines are currently being deployed, the adaptive immune determinants that promote viral clearance and confer protection remain poorly defined. Using mouse models of SARS-CoV-2, we demonstrate that both humoral and cellular adaptive immunity contribute to viral clearance in the setting of primary infection. Furthermore, we find that either convalescent mice or mice that receive mRNA vaccination are protected from both homologous infection and infection with a variant of concern, B.1.351. In addition, we find that this protection is largely mediated by antibody response and not cellular immunity. These results highlight the in vivo protective capacity of antibodies generated to both vaccine and natural infection.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Immunity, Humoral
/
COVID-19 Vaccines
/
SARS-CoV-2
/
COVID-19
/
Immunity, Cellular
Topics:
Vaccines
/
Variants
Limits:
Animals
Language:
English
Journal:
Sci Immunol
Year:
2021
Document Type:
Article
Affiliation country:
Sciimmunol.abl4509
Similar
MEDLINE
...
LILACS
LIS