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Perinatal Transmission and Outcome of Neonates Born to SARS-CoV-2-Positive Mothers: The Experience of 2 Highly Endemic Italian Regions.
Capozza, Manuela; Salvatore, Silvia; Baldassarre, Maria Elisabetta; Inting, Silvia; Panza, Raffaella; Fanelli, Margherita; Perniciaro, Simona; Morlacchi, Laura; Vimercati, Antonella; Agosti, Massimo; Laforgia, Nicola.
  • Capozza M; Section of Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology (DIMO), University of Bari "Aldo Moro", Bari, Italy.
  • Salvatore S; Neonatal and Pediatric Unit, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
  • Baldassarre ME; Section of Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology (DIMO), University of Bari "Aldo Moro", Bari, Italy.
  • Inting S; Section of Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology (DIMO), University of Bari "Aldo Moro", Bari, Italy.
  • Panza R; Section of Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology (DIMO), University of Bari "Aldo Moro", Bari, Italy.
  • Fanelli M; Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Bari, Italy.
  • Perniciaro S; Neonatal Intensive Care Unit, Department of Neonatology, Hospital "F. Del Ponte", Varese, Italy.
  • Morlacchi L; Neonatal Intensive Care Unit, Department of Neonatology, Hospital "F. Del Ponte", Varese, Italy.
  • Vimercati A; 2nd Unit of Obstetrics and Gynaecology, Department of Biomedical and Human Oncological Science (DIMO), University of Bari "Aldo Moro", Bari, Italy.
  • Agosti M; Neonatal and Pediatric Unit, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
  • Laforgia N; Section of Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology (DIMO), University of Bari "Aldo Moro", Bari, Italy.
Neonatology ; 118(6): 665-671, 2021.
Article in English | MEDLINE | ID: covidwho-1463073
ABSTRACT

INTRODUCTION:

COVID-19 is the disease caused by the novel coronavirus SARS-CoV-2, responsible of the pandemic declared in March 2020 and still ongoing. COVID-19 affects all ages but presents less complications and fatalities in children. Neonatal infections have rarely been reported worldwide, and vertical transmission is uncertain.

METHODS:

We conducted a prospective cohort study of all infants born to SARS-CoV-2-positive mothers admitted to 2 hospitals in South (Bari) and North (Varese) of Italy from April to December 2020. A molecular nasopharyngeal swab for SARS-CoV-2 using a reverse transcriptase polymerase chain reaction was made at birth for all enrolled newborns to evaluate vertical transmission of infection. We also evaluated postnatal transmission with a second nasopharyngeal swab made at 1 month of life and described maternal and neonatal clinical findings and short-term outcomes.

RESULTS:

176/179 (97%) newborns were SARS-CoV-2 negative at birth and 151/156 (97%) infants were still negative at 1 month of life. All newborns were asymptomatic. Seventy percent of newborns were breastfed during hospitalization. At 1 month of life, 76% of infants were breastfed.

CONCLUSION:

According to our results, vertical and perinatal infection is very rare. Breastfeeding does not increase the risk of COVID-19 and should be encouraged.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Child / Female / Humans / Infant / Infant, Newborn / Pregnancy Language: English Journal: Neonatology Journal subject: Perinatology Year: 2021 Document Type: Article Affiliation country: 000518060

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Child / Female / Humans / Infant / Infant, Newborn / Pregnancy Language: English Journal: Neonatology Journal subject: Perinatology Year: 2021 Document Type: Article Affiliation country: 000518060