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A review: Antibody-dependent enhancement in COVID-19: The not so friendly side of antibodies.
Sánchez-Zuno, Gabriela Athziri; Matuz-Flores, Mónica Guadalupe; González-Estevez, Guillermo; Nicoletti, Ferdinando; Turrubiates-Hernández, Francisco Javier; Mangano, Katia; Muñoz-Valle, José Francisco.
  • Sánchez-Zuno GA; Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.
  • Matuz-Flores MG; Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.
  • González-Estevez G; Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.
  • Nicoletti F; Department of Biomedical and Biotechnological Sciences, 9298University of Catania, Catania, Italy.
  • Turrubiates-Hernández FJ; Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.
  • Mangano K; Department of Biomedical and Biotechnological Sciences, 9298University of Catania, Catania, Italy.
  • Muñoz-Valle JF; Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.
Int J Immunopathol Pharmacol ; 35: 20587384211050199, 2021.
Article in English | MEDLINE | ID: covidwho-1463209
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents an unprecedented global public health emergency with economic and social consequences. One of the main concerns in the development of vaccines is the antibody-dependent enhancement phenomenon, better known as ADE. In this review, we provide an overview of SARS-CoV-2 infection as well as the immune response generated by the host. On the bases of this principle, we also describe what is known about the ADE phenomenon in various viral infections and its possible role as a limiting factor in the development of new vaccines and therapeutic strategies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibody-Dependent Enhancement / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines Limits: Humans Language: English Journal: Int J Immunopathol Pharmacol Journal subject: Allergy and Immunology / Pharmacology / Pathology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibody-Dependent Enhancement / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines Limits: Humans Language: English Journal: Int J Immunopathol Pharmacol Journal subject: Allergy and Immunology / Pharmacology / Pathology Year: 2021 Document Type: Article