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Prognostic factors of depression and depressive symptoms after hip fracture surgery: systematic review.
Milton-Cole, R; Ayis, S; Lambe, K; O'Connell, M D L; Sackley, C; Sheehan, K J.
  • Milton-Cole R; Department of Population Health Sciences, King's College London, School of Population Health and Environmental Sciences, Guy's Campus, London, SE1 1UL, UK. rhian.1.milton-cole@kcl.ac.uk.
  • Ayis S; Department of Population Health Sciences, King's College London, School of Population Health and Environmental Sciences, Guy's Campus, London, SE1 1UL, UK.
  • Lambe K; Department of Population Health Sciences, King's College London, School of Population Health and Environmental Sciences, Guy's Campus, London, SE1 1UL, UK.
  • O'Connell MDL; Department of Population Health Sciences, King's College London, School of Population Health and Environmental Sciences, Guy's Campus, London, SE1 1UL, UK.
  • Sackley C; Department of Population Health Sciences, King's College London, School of Population Health and Environmental Sciences, Guy's Campus, London, SE1 1UL, UK.
  • Sheehan KJ; Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, UK.
BMC Geriatr ; 21(1): 537, 2021 10 10.
Article in English | MEDLINE | ID: covidwho-1463233
ABSTRACT

BACKGROUND:

Patients with hip fracture and depression are less likely to recover functional ability. This review sought to identify prognostic factors of depression or depressive symptoms up to 1 year after hip fracture surgery in adults. This review also sought to describe proposed underlying mechanisms for their association with depression or depressive symptoms.

METHODS:

We searched for published (MEDLINE, Embase, PsychInfo, CINAHL and Web of Science Core Collection) and unpublished (OpenGrey, Greynet, BASE, conference proceedings) studies. We did not impose any date, geographical, or language limitations. Screening (Covidence), extraction (Checklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies, adapted for use with prognostic factors studies Checklist), and quality appraisal (Quality in Prognosis Studies tool) were completed in duplicate. Results were summarised narratively.

RESULTS:

In total, 37 prognostic factors were identified from 12 studies included in this review. The quality of the underlying evidence was poor, with all studies at high risk of bias in at least one domain. Most factors did not have a proposed mechanism for the association. Where factors were investigated by more than one study, the evidence was often conflicting.

CONCLUSION:

Due to conflicting and low quality of available evidence it is not possible to make clinical recommendations based on factors prognostic of depression or depressive symptoms after hip fracture. Further high-quality research investigating prognostic factors is warranted to inform future intervention and/or stratified approaches to care after hip fracture. TRIAL REGISTRATION Prospero registration CRD42019138690 .
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Depression / Hip Fractures Subject: Depression / Hip Fractures Type of study: Diagnostic study / Etiology study / Prognostic study / Systematic review Language: English Journal: BMC Geriatr Clinical aspect: Etiology / Prediction / Prognosis / Therapy Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Depression / Hip Fractures Subject: Depression / Hip Fractures Type of study: Diagnostic study / Etiology study / Prognostic study / Systematic review Language: English Journal: BMC Geriatr Clinical aspect: Etiology / Prediction / Prognosis / Therapy Year: 2021
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