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Does diabetes mellitus mitigate the gender gap in COVID-19 mortality?
Kautzky-Willer, Alexandra.
  • Kautzky-Willer A; Department of Internal Medicine III, Clinical Division of Endocrinology and Metabolism, Gender Medicine Unit, Medical University of Vienna, Vienna, Austria.
Eur J Endocrinol ; 185(5): C13-C17, 2021 Oct 08.
Article in English | MEDLINE | ID: covidwho-1463338
ABSTRACT
In this SARS-COV2-pandemic, diabetes mellitus (DM) soon emerged as one of the most prominent risk factors for a severe course of corona virus disease-2019 (COVID-19) and increased mortality due to hyperglycemia/insulin resistance, obesity, inflammation, altered immune status, and cardiovascular complications. In general, men are at a higher risk of severe or fatal COVID-19 disease irrespective of age, region and despite comparable infection rates in both sexes. In COVID-19, there is also a male predominance among hospitalized patients with diabetes, however, overall, data among patients with diabetes are ambiguous so far. Of note, similar to cardiovascular complications, women with type 2 diabetes (DM2) appear to lose their biological female advantage resulting in comparable death rates to those of men. The complex interplay of biological and behavioral factors, which may put men at greater risk of a severe or fatal course of COVID-19, and gender-related psychosocial factors, which may cause disadvantage to women concerning the infection rates, might explain why sex-disaggregated data among infected patients with diabetes are conflicting. Better knowledge on biological factors leading to functionally different immune responses and of gender-sensitive sociocultural determinants of COVID-19 infection rates may help to optimize prevention and management in the high-risk groups of men and women with diabetes.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Diabetes Complications / Diabetes Mellitus / Diabetes Mellitus, Type 2 / COVID-19 Subject: Diabetes Complications / Diabetes Mellitus / Diabetes Mellitus, Type 2 / COVID-19 Type of study: Determinantes_sociais_saude / Equity and inequality / Risk factors Language: English Journal: Eur J Endocrinol Clinical aspect: Etiology / Prognosis / Therapy Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Diabetes Complications / Diabetes Mellitus / Diabetes Mellitus, Type 2 / COVID-19 Subject: Diabetes Complications / Diabetes Mellitus / Diabetes Mellitus, Type 2 / COVID-19 Type of study: Determinantes_sociais_saude / Equity and inequality / Risk factors Language: English Journal: Eur J Endocrinol Clinical aspect: Etiology / Prognosis / Therapy Year: 2021
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