Medicines for malaria venture COVID box: A source for repurposing drugs with antifungal activity against human pathogenic fungi
Antifungal activity COVID Box Drug repurposing Pathogenic fungi
; 2021(Memorias do Instituto Oswaldo Cruz)
Article
in English
| WHO COVID | ID: covidwho-1463351
ABSTRACT
BACKGROUND:
Treatment of mycoses is often ineffective, usually prolonged, and has some side effects. These facts highlight the importance of discovering new molecules to treat fungal infections.OBJECTIVES:
To search the Medicines for Malaria Venture COVID Box for drugs with antifungal activity.METHODS:
Fourteen human pathogenic fungi were tested against the 160 drugs of this collection at 1.0 µM concentration. We evaluated the ability of the drugs to impair fungal growth, their fungicidal nature, and morphological changes caused to cells.FINDINGS:
Thirty-four molecules (21.25%) presented antifungal activity. Seven are antifungal drugs and one is the agricultural fungicide cycloheximide. The other drugs with antifungal activity included antibiotics (n=3), antimalarials (n=4), antivirals (n=2), antiparasitcs (n=3), antitumor agents (n=5), nervous system agents (n=3), immunosuppressants (n=3), antivomiting (n=1), antiasthmatic (n=1), and a genetic disorder agent (n=1). Several of these drugs inhibited Histoplasma capsulatum and Paracoccidioides brasiliensis growth (15 and 20, respectively), while Fusarium solani was not affected by the drugs tested. Most drugs were fungistatic, but niclosamide presented fungicidal activity against the three dimorphic fungi tested. Cyclosporine affected morphology of Cryptococcus neoformans. MAINCONCLUSIONS:
These drugs represent new alternatives to the development of more accessible and effective therapies to treat human fungal infections. © 2021, Fundacao Oswaldo Cruz. All rights reserved.
Full text:
Available
Collection:
Databases of international organizations
Database:
WHO COVID
Type of study:
Experimental Studies
Language:
English
Journal:
Antifungal activity COVID Box Drug repurposing Pathogenic fungi
Document Type:
Article
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