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A Comprehensive Review of Pharmacokinetics and Pharmacodynamics in Animals: Exploration of Interaction with Antibiotics of Shuang-Huang- Lian Preparations.
Liang, Liuyi; Jin, Xin; Li, Jinjing; Li, Rong; Jiao, Xinyi; Ma, Yuanyuan; Liu, Rui; Li, Zheng.
  • Liang L; College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyang Lake Road, West Zone of Tuanbo New City, Jinghai District, Tianjin 301617, China.
  • Jin X; Military Medicine Section, Logistics University of Chinese People\'s Armed Police Force, 1 Huizhihuan Road, Dongli District, Tianjin 300309, China.
  • Li J; College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyang Lake Road, West Zone of Tuanbo New City, Jinghai District, Tianjin 301617, China.
  • Li R; Military Medicine Section, Logistics University of Chinese People\'s Armed Police Force, 1 Huizhihuan Road, Dongli District, Tianjin 300309, China.
  • Jiao X; College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyang Lake Road, West Zone of Tuanbo New City, Jinghai District, Tianjin 301617, China.
  • Ma Y; College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyang Lake Road, West Zone of Tuanbo New City, Jinghai District, Tianjin 301617, China.
  • Liu R; College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyang Lake Road, West Zone of Tuanbo New City, Jinghai District, Tianjin 301617, China.
  • Li Z; College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyang Lake Road, West Zone of Tuanbo New City, Jinghai District, Tianjin 301617, China.
Curr Top Med Chem ; 22(2): 83-94, 2022.
Article in English | MEDLINE | ID: covidwho-1725177
ABSTRACT
As a traditional Chinese medicine (TCM), Shuang-Huang-Lian (SHL) has been widely used for treating infectious diseases of the respiratory tract such as encephalitis, pneumonia, and asthma. During the past few decades, considerable research has focused on pharmacological action, pharmacokinetic interaction with antibiotics, and clinical applications of SHL. A huge and more recent body of pharmacokinetic studies support the combination of SHL and antibiotics have different effects such as antagonism and synergism. SHL has been one of the best-selling TCM products. However, there is no systematic review of SHL preparations, ranging from protection against respiratory tract infections to interaction with antibiotics. Since their important significance in clinical therapy, the pharmacodynamics, pharmacokinetics, and interactions with antibiotics of SHL were reviewed and discussed. In addition, this review attempts to explore the possible potential mechanism of SHL preparations in the prevention and treatment of COVID-19. We are concerned about the effects of SHL against viruses and bacteria, as well as its interactions with antibiotics in an attempt to provide a new strategy for expanding the clinical research and medication of SHL preparations.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drugs, Chinese Herbal / COVID-19 Type of study: Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Traditional medicine Limits: Humans Language: English Journal: Curr Top Med Chem Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: 1568026621666211012111442

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drugs, Chinese Herbal / COVID-19 Type of study: Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Traditional medicine Limits: Humans Language: English Journal: Curr Top Med Chem Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: 1568026621666211012111442