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COVID-19, Hyperglycemia, and New-Onset Diabetes.
Khunti, Kamlesh; Del Prato, Stefano; Mathieu, Chantal; Kahn, Steven E; Gabbay, Robert A; Buse, John B.
  • Khunti K; Diabetes Research Centre, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, U.K. kk22@leicester.ac.uk.
  • Del Prato S; Section of Diabetes, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Mathieu C; Laboratory for Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
  • Kahn SE; VA Puget Sound Health Care System and University of Washington, Seattle, WA.
  • Gabbay RA; Harvard Medical School, Boston, MA.
  • Buse JB; American Diabetes Association, Arlington, VA.
Diabetes Care ; 44(12): 2645-2655, 2021 12.
Article in English | MEDLINE | ID: covidwho-1463413
ABSTRACT
Certain chronic comorbidities, including diabetes, are highly prevalent in people with coronavirus disease 2019 (COVID-19) and are associated with an increased risk of severe COVID-19 and mortality. Mild glucose elevations are also common in COVID-19 patients and associated with worse outcomes even in people without diabetes. Several studies have recently reported new-onset diabetes associated with COVID-19. The phenomenon of new-onset diabetes following admission to the hospital has been observed previously with other viral infections and acute illnesses. The precise mechanisms for new-onset diabetes in people with COVID-19 are not known, but it is likely that a number of complex interrelated processes are involved, including previously undiagnosed diabetes, stress hyperglycemia, steroid-induced hyperglycemia, and direct or indirect effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the ß-cell. There is an urgent need for research to help guide management pathways for these patients. In view of increased mortality in people with new-onset diabetes, hospital protocols should include efforts to recognize and manage acute hyperglycemia, including diabetic ketoacidosis, in people admitted to the hospital. Whether new-onset diabetes is likely to remain permanent is not known, as the long-term follow-up of these patients is limited. Prospective studies of metabolism in the setting of postacute COVID-19 will be required to understand the etiology, prognosis, and treatment opportunities.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetic Ketoacidosis / Diabetes Mellitus / COVID-19 / Hyperglycemia Type of study: Cohort study / Etiology study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Diabetes Care Year: 2021 Document Type: Article Affiliation country: Dc21-1318

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetic Ketoacidosis / Diabetes Mellitus / COVID-19 / Hyperglycemia Type of study: Cohort study / Etiology study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Diabetes Care Year: 2021 Document Type: Article Affiliation country: Dc21-1318