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Profile of Immunoglobulin G N-Glycome in COVID-19 Patients: A Case-Control Study.
Hou, Haifeng; Yang, Huan; Liu, Pengcheng; Huang, Changwu; Wang, Meng; Li, Yuejin; Zhu, Mingsong; Wang, Jing; Xu, Yuan; Wang, Youxin; Ma, Qingwei; Li, Dong; Liao, Pu; Wang, Wei.
  • Hou H; School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, China.
  • Yang H; School of Clinical Medicine, Southwest Medical University, Luzhou, China.
  • Liu P; Department of Clinical Laboratory, Chongqing General Hospital, Chongqing, China.
  • Huang C; School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, China.
  • Wang M; Department of Clinical Laboratory, The Fifth People's Hospital of Chongqing & Chongqing Renji Hospital, University of Chinese Academy of Sciences, Chongqing, China.
  • Li Y; School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, China.
  • Zhu M; School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, China.
  • Wang J; Department of Clinical Laboratory, Chongqing General Hospital, Chongqing, China.
  • Xu Y; Department of Clinical Laboratory, Chongqing Public Health Medical Center, Chongqing, China.
  • Wang Y; Department of Clinical Laboratory, Chongqing General Hospital, Chongqing, China.
  • Ma Q; Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China.
  • Li D; Testing Center, Bioyong Technologics, Inc., Beijing, China.
  • Liao P; School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, China.
  • Wang W; Department of Clinical Laboratory, Chongqing General Hospital, Chongqing, China.
Front Immunol ; 12: 748566, 2021.
Article in English | MEDLINE | ID: covidwho-1463474
ABSTRACT
Coronavirus disease 2019 (COVID-19) remains a major health challenge globally. Previous studies have suggested that changes in the glycosylation of IgG are closely associated with the severity of COVID-19. This study aimed to compare the profiles of IgG N-glycome between COVID-19 patients and healthy controls. A case-control study was conducted, in which 104 COVID-19 patients and 104 age- and sex-matched healthy individuals were recruited. Serum IgG N-glycome composition was analyzed by hydrophilic interaction liquid chromatography with the ultra-high-performance liquid chromatography (HILIC-UPLC) approach. COVID-19 patients have a decreased level of IgG fucosylation, which upregulates antibody-dependent cell cytotoxicity (ADCC) in acute immune responses. In severe cases, a low level of IgG sialylation contributes to the ADCC-regulated enhancement of inflammatory cytokines. The decreases in sialylation and galactosylation play a role in COVID-19 pathogenesis via the activation of the lectin-initiated alternative complement pathway. IgG N-glycosylation underlines the complex clinical phenotypes of SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / SARS-CoV-2 / COVID-19 Type of study: Observational study / Risk factors Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.748566

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunoglobulin G / SARS-CoV-2 / COVID-19 Type of study: Observational study / Risk factors Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.748566