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Sensitivity of SARS-CoV-2 Variants to Neutralization by Convalescent Sera and a VH3-30 Monoclonal Antibody.
Yue, Shuai; Li, Zhirong; Lin, Yao; Yang, Yang; Yuan, Mengqi; Pan, Zhiwei; Hu, Li; Gao, Leiqiong; Zhou, Jing; Tang, Jianfang; Wang, Yifei; Tian, Qin; Hao, Yaxing; Wang, Juan; Huang, Qizhao; Xu, Lifan; Zhu, Bo; Liu, Pinghuang; Deng, Kai; Wang, Li; Ye, Lilin; Chen, Xiangyu.
  • Yue S; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Li Z; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Lin Y; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Yang Y; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Yuan M; Department of Stomatology, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, China.
  • Pan Z; College of Veterinary Medicine, China Agricultural University, Beijing, China.
  • Hu L; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Gao L; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Zhou J; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Tang J; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Wang Y; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Tian Q; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Hao Y; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Wang J; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Huang Q; Department of Emergency Medicine, Southwest Hospital, Third Military Medical University, Chongqing, China.
  • Xu L; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Zhu B; Institute of Immunology, Third Military Medical University, Chongqing, China.
  • Liu P; Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
  • Deng K; College of Veterinary Medicine, China Agricultural University, Beijing, China.
  • Wang L; Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
  • Ye L; Infectious Diseases Institute, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Chen X; Institute of Immunology, Third Military Medical University, Chongqing, China.
Front Immunol ; 12: 751584, 2021.
Article in English | MEDLINE | ID: covidwho-1463475
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of novel coronavirus disease (COVID-19). Though vaccines and neutralizing monoclonal antibodies (mAbs) have been developed to fight COVID-19 in the past year, one major concern is the emergence of SARS-CoV-2 variants of concern (VOCs). Indeed, SARS-CoV-2 VOCs such as B.1.1.7 (UK), B.1.351 (South Africa), P.1 (Brazil), and B.1.617.1 (India) now dominate the pandemic. Herein, we found that binding activity and neutralizing capacity of sera collected from convalescent patients in early 2020 for SARS-CoV-2 VOCs, but not non-VOC variants, were severely blunted. Furthermore, we observed evasion of SARS-CoV-2 VOCs from a VH3-30 mAb 32D4, which was proved to exhibit highly potential neutralization against wild-type (WT) SARS-CoV-2. Thus, these results indicated that SARS-CoV-2 VOCs might be able to spread in convalescent patients and even harbor resistance to medical countermeasures. New interventions against these SARS-CoV-2 VOCs are urgently needed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Mutation Topics: Vaccines / Variants Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.751584

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Mutation Topics: Vaccines / Variants Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.751584