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Previous Vitamin D Supplementation and Morbidity and Mortality Outcomes in People Hospitalised for COVID19: A Cross-Sectional Study.
Arroyo-Díaz, Juan Antonio; Julve, Josep; Vlacho, Bogdan; Corcoy, Rosa; Ponte, Paola; Román, Eva; Navas-Méndez, Elena; Llauradó, Gemma; Franch-Nadal, Josep; Domingo, Pere; Mauricio, Didac.
  • Arroyo-Díaz JA; Infectious Diseases, Department of Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • Julve J; Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • Vlacho B; Diabetis des de l'Atenció Primària (DAP)-Cat Group, Unitat de Suport a la Recerca Barcelona, University Institute for Primary Care Research (Institut Universitari per a la recerca a l'Atenció Primària (IDIAP) Jordi Gol), Barcelona, Spain.
  • Corcoy R; Center for Biomedical Research in the Network in Bioengineering, Biomaterials, and Nanomedicine, Madrid, Spain.
  • Ponte P; Department of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • Román E; Department of Medicine, Faculty of Medicine, Autonomous University of Barcelona, Barcelona, Spain.
  • Navas-Méndez E; Department of Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • Llauradó G; Department of Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
  • Franch-Nadal J; Unitat de Suport a la Recerca Barcelona, University Institute for Primary Care Research (IDIAP Jordi Gol), Barcelona, Spain.
  • Domingo P; Department of Endocrinology and Nutrition, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.
  • Mauricio D; Centro de Investigación Biomédica en Red (CIBER) of Diabetes and Associated Metabolic Diseases, Instituto de Salud Carlos III, Madrid, Spain.
Front Public Health ; 9: 758347, 2021.
Article in English | MEDLINE | ID: covidwho-1463526
ABSTRACT

Aim:

The study aim was to assess the association of vitamin D supplementation before hospital admission and severe outcomes in subjects admitted for COVID-19.

Methods:

We performed a cross-sectional analysis of pseudonymised medical record data from subjects admitted to the Hospital de la Santa Creu i Sant Pau (Barcelona, Spain) for COVID-19 during March and April 2020. The composite primary study outcome was defined as death and/or invasive mechanical ventilation (IMV). Association between risk factors and study outcomes was evaluated by bivariate analysis, followed by logistic regression analysis.

Results:

In total, 1,267 persons were hospitalised during the observation period. Overall, 14.9% of the subjects were on active vitamin D supplementation treatment before admission. The subjects in the vitamin D group were significantly older than subjects without vitamin D supplementation. We observed higher rates of the primary outcome (death and/or IMV) among the persons with previous use of vitamin D (30.1 vs. 22.9% in those not receiving treatment). In the bivariate analysis, previous use of vitamin D was positively associated with death and/or IMV [odds ratio (OR) 1.45 95% CI 1.03; 2.04]; however, after adjustment for other risk factors this association disappeared (OR 1.09 95%CI 0.65; 1.81).

Conclusion:

We did not find an association between vitamin D supplementation before hospital admission and death and/or IMV in subjects admitted for COVID-19. The age and the burden of age-associated comorbidities were independently associated with the in-hospital events.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Vitamin D / COVID-19 Subject: Vitamin D / COVID-19 Type of study: Prevalence study / Risk factors Language: English Journal: Front Public Health Clinical aspect: Etiology Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Vitamin D / COVID-19 Subject: Vitamin D / COVID-19 Type of study: Prevalence study / Risk factors Language: English Journal: Front Public Health Clinical aspect: Etiology Year: 2021
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