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Hyaluronic Acid-Dexamethasone Nanoparticles for Local Adjunct Therapy of Lung Inflammation.
Camara, Candelaria Ines; Bertocchi, Laura; Ricci, Caterina; Bassi, Rosaria; Bianchera, Annalisa; Cantu', Laura; Bettini, Ruggero; Del Favero, Elena.
  • Camara CI; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, LITA, Via Fratelli Cervi 93, 20090 Segrate, Italy.
  • Bertocchi L; Instituto de Investigaciones en Fisicoquímica de Córdoba (INFIQC), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Córdoba 5000, Argentina.
  • Ricci C; Department of Food and Drug, Università di Parma, Parco Area delle Scienze, 27/A, 43124 Parma, Italy.
  • Bassi R; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, LITA, Via Fratelli Cervi 93, 20090 Segrate, Italy.
  • Bianchera A; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, LITA, Via Fratelli Cervi 93, 20090 Segrate, Italy.
  • Cantu' L; Department of Food and Drug, Università di Parma, Parco Area delle Scienze, 27/A, 43124 Parma, Italy.
  • Bettini R; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, LITA, Via Fratelli Cervi 93, 20090 Segrate, Italy.
  • Del Favero E; Department of Food and Drug, Università di Parma, Parco Area delle Scienze, 27/A, 43124 Parma, Italy.
Int J Mol Sci ; 22(19)2021 Sep 28.
Article in English | MEDLINE | ID: covidwho-1463704
ABSTRACT
The delivery of a dexamethasone formulation directly into the lung appears as an appropriate strategy to strengthen the systemic administration, reducing the dosage in the treatment of lung severe inflammations. For this purpose, a hyaluronic acid-dexamethasone formulation was developed, affording an inhalable reconstituted nanosuspension suitable to be aerosolized. The physico-chemical and biopharmaceutical properties of the formulation were tested size, stability, loading of the spray-dried dry powder, reconstitution capability upon redispersion in aqueous media. Detailed structural insights on nanoparticles after reconstitution were obtained by light and X-ray scattering techniques. (1) The size of the nanoparticles, around 200 nm, is in the proper range for a possible engulfment by macrophages. (2) Their structure is of the core-shell type, hosting dexamethasone nanocrystals inside and carrying hyaluronic acid chains on the surface. This specific structure allows for nanosuspension stability and provides nanoparticles with muco-inert properties. (3) The nanosuspension can be efficiently aerosolized, allowing for a high drug fraction potentially reaching the deep lung. Thus, this formulation represents a promising tool for the lung administration via nebulization directly in the pipe of ventilators, to be used as such or as adjunct therapy for severe lung inflammation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Dexamethasone / Nanoparticles / Hyaluronic Acid Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms221910480

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Dexamethasone / Nanoparticles / Hyaluronic Acid Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms221910480